EP 0216901 A4 19891004 - IMMUNOGENIC ANTIGEN-CARRIER PROTEIN CONJUGATE FOR USE IN A VACCINE AGAINST MALARIA.
Title (en)
IMMUNOGENIC ANTIGEN-CARRIER PROTEIN CONJUGATE FOR USE IN A VACCINE AGAINST MALARIA.
Title (de)
IMMUNOGENES ANTIGEN-TRÄGER-PROTEINKONJUGAT ZUR VERWENDUNG IN IMPFSTOFFEN GEGEN MALARIA.
Title (fr)
CONJUGUE PROTEINIQUE IMMUNOGENIQUE PORTEUR D'ANTIGENES, DESTINE A ETRE UTILISE DANS UN VACCIN CONTRE LA MALARIA.
Publication
Application
Priority
US 71696085 A 19850328
Abstract (en)
[origin: WO8605790A1] A conjugate comprising a synthetic immunogenic peptide, which hasan amino acid sequence corresponding to that of an immunodominant epitope of the circumsporozoite protein of the malaria parasite P. falciparum and a carrier protein selected from the group consisting of carrier proteins used in vaccine preparations.
IPC 1-7
A61K 37/02; A61K 39/00; C07K 5/00; C07K 7/08; C07K 15/12; C07K 17/00
IPC 8 full level
C07K 7/08 (2006.01); A61K 39/015 (2006.01); C07K 14/00 (2006.01); C07K 14/44 (2006.01); C07K 14/445 (2006.01); C07K 19/00 (2006.01)
CPC (source: EP)
A61K 39/015 (2013.01); C07K 14/445 (2013.01); A61K 2039/6037 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
- [YP] EP 0166410 A2 19860102 - US COMMERCE [US]
- [YP] WO 8600911 A1 19860213 - UNIV NEW YORK [US]
- [YP] US 4554101 A 19851119 - HOPP THOMAS P [US]
- [Y] CELL, vol. 37, July 1984, pages 767-778, MIT; A. WILSON et al.: "The structure of an antigenic determinant in a protein"
- [Y] SCIENCE, vol. 225, 10th August 1984, pages 593-599; J.B. DAME et al.: "Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite plasmodium falciparum"
- [Y] SCIENCE, vol. 225, 10th August 1984, pages 628-629; V. ENEA et al.: "DNA cloning of plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope"
- [Y] EXP. MED., vol. 153, June 1983, pages 1947-1957, The Rockefeller University Press; F. ZAVALA et al.: "Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes"
- [Y] MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 5, 1982, pages 391-400, Elsevier Biomedical Press; M. GOMAN et al.: "The establishment of genomic DNA libraries for the human malaria parasite plasmodium falciparum and identification of individual clones by hybridisation"
- [XP] SCIENCE, vol. 228, 24th May 1985, pages 996-999, Washington, US; R. BALLOU: "Immunogenicity of synthetic peptides from circumsporozoite protein of plasmodium falciparum"
- [YP] CHEMICAL ABSTRACTS, vol. 104, no. 3, 20th January 1986, page 18, abstract no. 14545j, Columbus, Ohio, US; E.R. CLOUGH et al.: "Production of antisporozoite antibodies in absence of response to carrier by coupling an MDP derivative to a malaria peptide-tetanus toxoid conjugate", & BIOCHEM. BIOPHYS. RES. COMMUN. 1985, 131(1), 70-6
- [YP] SCIENCE, vol. 228, 21st June 1985, pages 1436-1440; F. ZAVALA et al.: "Rationale for development of a synthetic vaccine against plasmodium falciparum malaria"
- See references of WO 8605790A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8605790 A1 19861009; AU 5695686 A 19861023; EP 0216901 A1 19870408; EP 0216901 A4 19891004; ES 553425 A0 19871101; ES 8800273 A1 19871101; IE 860846 L 19860928; IL 78292 A0 19860731; JP S62502340 A 19870910; PT 82282 A 19860401; PT 82282 B 19880217; ZA 862376 B 19861126
DOCDB simple family (application)
US 8600627 W 19860327; AU 5695686 A 19860327; EP 86902613 A 19860327; ES 553425 A 19860326; IE 84686 A 19860327; IL 7829286 A 19860327; JP 50226786 A 19860327; PT 8228286 A 19860326; ZA 862376 A 19860401