EP 0221725 A3 19880323 - PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS
Title (en)
PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS
Publication
Application
Priority
GB 8526209 A 19851023
Abstract (en)
[origin: EP0221725A2] A compound of formula (I)is prepared by cyclising a compound of formula (IIa) or (IIb) or a mixture thereofwhereinX is hydroxyl or halogen andR' and R<sup>2</sup> independently, represent hydroxy protecting groups)followed by removal of the protecting groups R<sup>1</sup> and R<sup>2</sup>.The compound (I) is of use as an intermediate inthestere- oselective preparation of (±)trans -5-fluoro-2,3,3a,9a-tetra- hydro-1H-[1,4]benzodioxino[2,3-c) pyrrole, which is a selective α<sub>2</sub>-adrenoreceptor antagonist and is thus of potential value, in particular, for the treatment or prevention of depression.
IPC 1-7
IPC 8 full level
A61K 31/335 (2006.01); A61K 31/357 (2006.01); A61P 25/24 (2006.01); A61P 25/26 (2006.01); B01J 31/00 (2006.01); C07B 61/00 (2006.01); C07C 43/23 (2006.01); C07D 319/20 (2006.01); C07D 491/04 (2006.01); C07D 491/056 (2006.01)
CPC (source: EP US)
A61P 25/24 (2017.12 - EP); A61P 25/26 (2017.12 - EP); C07C 43/23 (2013.01 - EP US); C07D 319/20 (2013.01 - EP US); C07D 491/04 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Citation (search report)
- [A] GB 1102880 A 19680214 - MERCK AG E
- [A] FR 78580 E 19620810 - THOMAE GMBH DR K
- [A] FR 2534921 A1 19840427 - GLAXO GROUP LTD [GB]
- [AP] GB 2157691 A 19851030 - GLAXO GROUP LTD
Designated contracting state (EPC)
AT BE CH DE ES FR GB GR IT LI NL SE
DOCDB simple family (publication)
EP 0221725 A2 19870513; EP 0221725 A3 19880323; EP 0221725 B1 19900808; AT E55385 T1 19900815; DE 3673325 D1 19900913; ES 2017464 B3 19910216; GB 8526209 D0 19851127; GR 3000742 T3 19911010; JP S62174068 A 19870730; US 4837336 A 19890606
DOCDB simple family (application)
EP 86308207 A 19861022; AT 86308207 T 19861022; DE 3673325 T 19861022; ES 86308207 T 19861022; GB 8526209 A 19851023; GR 900400355 T 19900831; JP 25155686 A 19861022; US 92225586 A 19861023