EP 0229107 A1 19870722 - PROTECTIVE HUMAN MONOCLONAL ANTIBODIES TO -i(PSEUDOMONAS AERUGINOSA) EXOTOXIN A.
Title (en)
PROTECTIVE HUMAN MONOCLONAL ANTIBODIES TO -i(PSEUDOMONAS AERUGINOSA) EXOTOXIN A.
Title (de)
MENSCHLICHE MONOKLONALE ANTIKÖRPER GEGEN PSEUDOMONAS-AERUGINOSA-EXOTOXIN.
Title (fr)
ANTICORPS MONOCLONAUX HUMAINS DE PROTECTION CONTRE L'EXOTOXINE A PRODUITE PAR -i(PSEUDOMONAS AERUGINOSA).
Publication
Application
Priority
US 74217085 A 19850606
Abstract (en)
[origin: WO8607382A1] Cell lines have been produced that secrete human monoclonal antibodies capable of binding to and neutralizing Pseudomanas aeruginosa exotoxin A. These antibodies have been found to be protective against lethal challenges of the exotoxin. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.
Abstract (fr)
Des lignées cellulaires sécrètent des anticorps monoclonaux humains capables de se lier à l'exotoxine A produite par Pseudomonas Aeruginosa et de la neutraliser. Ces anticorps protègent contre les atteintes mortelles de l'exotoxines. Des compositions pharmaceutiques contiennent ces anticorps, éventuellement combinés à d'autres anticorps monoclonaux, à des fractions de plasma sanguin et à des agents antimicrobiens. Ces compositions peuvent être utilisées de façon prophylactique et thérapeutique pour réduire des infections.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); C07K 14/005 (2006.01); C07K 14/195 (2006.01); C07K 14/41 (2006.01); C07K 16/00 (2006.01); C07K 16/12 (2006.01); C12N 5/00 (2006.01); C12N 5/10 (2006.01); C12N 15/00 (2006.01); C12N 15/02 (2006.01); C12P 21/00 (2006.01); C12P 21/08 (2006.01); A61K 38/00 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
C07K 16/1214 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8607382 A1 19861218; AU 5991786 A 19870107; AU 6658390 A 19910314; DK 59387 A 19870205; DK 59387 D0 19870205; EP 0229107 A1 19870722; EP 0229107 A4 19871109; ES 555741 A0 19870716; ES 8707296 A1 19870716; FI 870482 A0 19870205; FI 870482 A 19870205; HU 205630 B 19920528; HU T42135 A 19870629; IE 861494 L 19861206; IL 79010 A0 19860930; JP S63500035 A 19880107; NO 174003 B 19931122; NO 174003 C 19940302; NO 870457 L 19870205; ZA 864196 B 19870225
DOCDB simple family (application)
US 8601204 W 19860602; AU 5991786 A 19860602; AU 6658390 A 19901113; DK 59387 A 19870205; EP 86903954 A 19860602; ES 555741 A 19860605; FI 870482 A 19870205; HU 326586 A 19860602; IE 149486 A 19860605; IL 7901086 A 19860603; JP 50337186 A 19860602; NO 870457 A 19870205; ZA 864196 A 19860605