Global Patent Index - EP 0231374 A4

EP 0231374 A4 19890919 - INSERTION INTO ANIMALS OF GENES CODING FOR INTERFERON-INDUCED PROTEINS.

Title (en)

INSERTION INTO ANIMALS OF GENES CODING FOR INTERFERON-INDUCED PROTEINS.

Title (de)

EINBRINGEN VON FÜR INDUZIERTES INTERFERON KODIERENDEN GENEN IN TIERE.

Title (fr)

INSERTION DANS DES ANIMAUX DE GENES CODANT DES PROTEINES INDUITES PAR l'INTEFERON.

Publication

EP 0231374 A4 19890919 (EN)

Application

EP 86906512 A 19860731

Priority

US 76109285 A 19850731

Abstract (en)

[origin: WO8700864A1] Interferon-induced proteins having antiviral effects in animals; DNA sequences that code for such proteins and recombinant DNA molecules and transformed hosts that express such proteins; a method of producing an interferon-induced protein in an animal, in the absence of interferon induction or where there is insufficient expression of interferon-induced protein, comprising inserting into an animal a gene coding for such protein; and a method of protecting an animal from viral infection (e.g., influenza) comprising administering to the animal an antiviral-effective amount of an antiviral protein (e.g., Mx protein). The methods may be used to protect an animal against viral infection (e.g., influenza) by inserting a gene coding for an antiviral protein (e.g., Mx protein) into an animal that is susceptible to such infection or by administering a pharmaceutical composition comprising an antiviral-effective amount of such protein to an animal that is susceptible to such infection.

IPC 1-7

C12N 15/00; C12N 5/00; C12N 1/00; A61K 39/00; A01N 65/02

IPC 8 full level

C12N 15/09 (2006.01); A61K 31/70 (2006.01); A61K 38/21 (2006.01); C07H 21/04 (2006.01); C07K 14/00 (2006.01); C07K 14/005 (2006.01); C07K 14/195 (2006.01); C07K 14/47 (2006.01); C12N 5/10 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 14/4718 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [Y] US 4396601 A 19830802 - SALSER WINSTON A, et al
  • [XP] CELL, vol. 44, 17 January 1986, Campridge, Mass, US; P. Staeheli et al.: "Mx protein: Constitutive Expression in 3T3 Cells Transformed with Cloned mx cDNA Confers Selective Resistance to Influenza Virus", pages 147-158
  • [X] THE BIOLOGY OF THE INTERFERON SYSTEM 1984, M.A. Horisberger et al.: "The IFN-Induced Mouse protein Mx involved in the Mechanism of Resistance to Influenza Viruses: Purification and Characterization" published April 1985 by Elsevier Science Publishiers, New York, US, Pages 313-316
  • [X] CHEMICAL ABSTRACTS, vol. 92, no. 3, 21st January 1980, abs. 20444a, Columbus, Ohio, US; S.L Gupta et al.: "Interferon action: Induction of specific proteins in mouse and human cells by homologous interferons", & Proc. Natl. Acad. Sci. USA, 1979, vol3 76, no. 10, pages 4817-4821
  • [YD] LETTERS TO NATURE, vol. 315, June 1985, London, GB; Robert E. Hammer et al.; "Production of transgenic rabbits, sheep and pigs by microinjection", pages 680-683
  • [XPD] MOLECULAR AND CELLULAR BIOLOGY, vol.5, no. 8, August 1985, Washington DC, US, Peter Staeheli et al.: "Interferon-Induced Human protein with Homology to Protein Mx of Influenza Virus-Resistant Mice", Pages 2150-2153
  • [XP] CHEMICAL ABSTRACTS, vol 103, no. 15 14th October 1985, abs. 121427Y, Columbus, Ohio, US; John M. Kelly et al.: "Analysis of messenger RNAs induced in response to interferons in human cells", pages 53-59
  • [XD] JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 260, no. 3, 10th February 1985, M.A. Horisberger et al.: "An Interferon-induced Mouse Protein Involved in the Mechanism of Resistance to Influenza Viruses. Its Purification to Homogeneity and Chzaracterization by Polyclonal Antibodies", pages 1730-1733
  • [X] ANTIVIRAL RESEARCH, vol. 4, no. Spec. Cssue, 1984, Amsterdam, NL; P. Staeheli et al.: "Cloning of a Mouse cDNA Encoding the Interferon-Inducible Protein Mx Associated with Resistance Against Influenza Viruses", Page 5
  • [A] LETTERS TO NATURE, vol. 313, 28th February 1985, London, GB; K. Jacobs et al.: "Isolation and characterization of genomic and cDNA clones of Human erythropoietin", pages 806-810
  • See references of WO 8700864A1

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 8700864 A1 19870212; EP 0231374 A1 19870812; EP 0231374 A4 19890919; JP S63500800 A 19880324

DOCDB simple family (application)

US 8601818 W 19860731; EP 86906512 A 19860731; JP 50574986 A 19860731