Global Patent Index - EP 0236138 B1

EP 0236138 B1 19910807 - DIHYDROPYRAN DERIVATIVES

Title (en)

DIHYDROPYRAN DERIVATIVES

Publication

EP 0236138 B1 19910807 (EN)

Application

EP 87301909 A 19870305

Priority

GB 8605413 A 19860305

Abstract (en)

[origin: EP0236138A1] The invention relates to compounds of the formula I <CHEM> wherein: R1 is alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted) aryl, arylalkyl or silyl (bearing alkyl, aryl or arylalkyl substituents); R2 is hydrogen or alkyl; R3 is hydrogen, alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted), alkenyl, aryl, arylalkyl, amino, mono- or di- alkylamino or a group of the formula -OR5 wherein R5 is optionally substituted alkyl, aryl or arylalkyl; R4 is alkyl optionally substituted by one or more alkoxy groups or halogen atoms; Y is optionally substituted alkoxy or cycloalkoxy, arylalkoxy or a group of formula -NR6R7 wherein R6 is hydrogen or alkyl and R7 is alkyl, cycloalkyl (which alkyl and cycloalkyl groups may be substituted), aryl or arylalkyl or R7 is a group of formula -COOR8 wherein R8 is alkyl or arylalkyl, which are useful as intermediates in the synthesis of beta-lactam antibiotics, particularly carbapenems, and to a process for the manufacture of the said compounds.

IPC 1-7

C07D 205/08; C07D 309/30

IPC 8 full level

C07D 205/08 (2006.01); C07D 309/30 (2006.01)

CPC (source: EP US)

C07D 205/08 (2013.01 - EP US); C07D 309/30 (2013.01 - EP US)

Citation (examination)

  • The Journal of antibiotics, vol XXXVI, no 9, 1983, pp1109-1115
  • Tetrahedron letters, vol 21 , pp 2783-2786, 1980
  • Canadian Journal of Chem. Communications, vol 60, 1982, pp 2292-2294
  • Chem. Pharm. Bull. 30(5) pp 1929-1931 (1982)

Designated contracting state (EPC)

AT BE CH DE ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0236138 A1 19870909; EP 0236138 B1 19910807; AT E65998 T1 19910815; DE 3771894 D1 19910912; ES 2038169 T3 19930716; GB 8605413 D0 19860409; JP S62265280 A 19871118; US 4962209 A 19901009

DOCDB simple family (application)

EP 87301909 A 19870305; AT 87301909 T 19870305; DE 3771894 T 19870305; ES 87301909 T 19870305; GB 8605413 A 19860305; JP 4900987 A 19870305; US 2096087 A 19870302