EP 0245669 B1 19931201 - Pharmaceutical preparation for preventing damage to living cells by free radicals, or for increasing the efficacy of organic sulphur compounds, and process for increasing the life span of isolated organs.
Title (en)
Pharmaceutical preparation for preventing damage to living cells by free radicals, or for increasing the efficacy of organic sulphur compounds, and process for increasing the life span of isolated organs.
Title (de)
Pharmazeutisches Präparat zur Verhütung der Schädigung lebender Zellen durch freie Radikale, beziehungsweise zur Erhöhung der Wirksamkeit von organischen Schwefelverbindungen und Verfahren zur Erhöhung der Lebensdauer isolierter Organe.
Title (fr)
Préparation pharmaceutique pour empêcher les dommages aux cellules vivantes par des radicaux libres, respectivement pour augmenter l'efficacité des composés organiques du soufre et procédé pour augmenter la durée de vie d'organes isolés.
Publication
Application
Priority
CH 196986 A 19860514
Abstract (en)
[origin: EP0245669A2] Pharmaceutical preparations which contain, as active substance, zinc salts or zinc complexes, are used for preventing damage to live cells by free radicals. Upon the action of ionising radiation, in the renewed blood circulation in organs following previous exsanguinity, and in the treatment of patients with oxygen, free radicals may damage the live cells, and also in isolated organs which are perfused with a perfusion medium, the live cells can suffer damage by free radicals. Using the zinc salts or zinc complexes, the damage could be reduced in all these cases, and in many cases the activity of the zinc salts or zinc complexes could even be increased by the presence of organic sulphur-containing compounds. Furthermore, there are described pharmaceutical preparations which are intended to increase the efficacy of such pharmaceutical preparations which contain organic sulphur compounds, the pharmaceutical preparations containing, as the active substance which shows a synergistic action together with the organic sulphur compounds, a salt of the metals zinc, cobalt, zirconium, magnesium or lithium or a complex compound of these metal ions. Examples of the sulphur-containing preparations whose efficacy can be increased by the preparations containing the abovementioned metal ions or metal complexes are preparations for the protection against irradiation or preparations for the treatment of liver diseases.
IPC 1-7
A61K 33/30; A61K 31/19; A61K 31/315; A61K 31/28; A61K 33/24; A61K 33/00; A61K 7/42
IPC 8 full level
A61K 8/27 (2006.01); A61K 8/46 (2006.01); A61K 31/195 (2006.01); A61K 31/28 (2006.01); A61K 31/315 (2006.01); A61K 33/00 (2006.01); A61K 33/24 (2006.01); A61K 33/30 (2006.01); A61K 45/06 (2006.01); A61Q 17/04 (2006.01)
CPC (source: EP)
A61K 8/27 (2013.01); A61K 8/46 (2013.01); A61K 31/28 (2013.01); A61K 31/315 (2013.01); A61K 33/00 (2013.01); A61K 33/30 (2013.01); A61Q 17/04 (2013.01); A61K 2800/58 (2013.01)
Citation (examination)
Burger's medicinal chemistry, 4(111) (1981), 34
Designated contracting state (EPC)
BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0245669 A2 19871119; EP 0245669 A3 19890329; EP 0245669 B1 19931201; DE 3788300 D1 19940113
DOCDB simple family (application)
EP 87105633 A 19870415; DE 3788300 T 19870415