EP 0253396 A2 19880120 - Process for preparing 5,6-substituted-2,4-quinazolinediamines and intermediates.
Title (en)
Process for preparing 5,6-substituted-2,4-quinazolinediamines and intermediates.
Title (de)
Verfahren zur Herstellung von 5,6-substituierten-2,4-Chinazolindiaminen und Zwischenprodukten.
Title (fr)
Procédé pour préparer des quinazolines 2,4-diamines substituées en 5,6 et intermédiaires.
Publication
Application
Priority
US 88646386 A 19860717
Abstract (en)
An improved process for the preparation of 6-substituted-5-alkyl-2,4-quinazolinediamines, useful in the production of trimetrexate and similar antifolate agents, together with several novel intermediates are disclosed.
IPC 1-7
IPC 8 full level
C07C 255/00 (2006.01); C07C 255/49 (2006.01); C07C 255/51 (2006.01); C07C 255/58 (2006.01); C07D 239/00 (2006.01); C07D 239/84 (2006.01); C07D 239/94 (2006.01); C07D 239/95 (2006.01)
IPC 8 main group level
CPC (source: EP KR US)
C07C 255/00 (2013.01 - EP US); C07D 239/95 (2013.01 - KR)
Designated contracting state (EPC)
AT BE CH DE ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
EP 0253396 A2 19880120; EP 0253396 A3 19890419; EP 0253396 B1 19930317; AT E86984 T1 19930415; AU 591305 B2 19891130; AU 7501287 A 19880121; CA 1282078 C 19910326; DE 3784795 D1 19930422; DE 3784795 T2 19930624; DK 368587 A 19880118; DK 368587 D0 19870715; ES 2053478 T3 19940801; FI 873125 A0 19870715; FI 873125 A 19880118; JP S6330474 A 19880209; KR 880001615 A 19880425; NO 872971 D0 19870716; NO 872971 L 19880118; NZ 221020 A 19900626; PH 23781 A 19891103; PT 85345 A 19870801; PT 85345 B 19900430; US 4677219 A 19870630; ZA 874651 B 19890222
DOCDB simple family (application)
EP 87110310 A 19870716; AT 87110310 T 19870716; AU 7501287 A 19870701; CA 540861 A 19870629; DE 3784795 T 19870716; DK 368587 A 19870715; ES 87110310 T 19870716; FI 873125 A 19870715; JP 17609287 A 19870716; KR 870007685 A 19870716; NO 872971 A 19870716; NZ 22102087 A 19870709; PH 35547 A 19870715; PT 8534587 A 19870716; US 88646386 A 19860717; ZA 874651 A 19870626