Global Patent Index - EP 0260880 A3

EP 0260880 A3 19900307 - TURNING ON OF CYTOTOXICITY

Title (en)

TURNING ON OF CYTOTOXICITY

Publication

EP 0260880 A3 19900307 (EN)

Application

EP 87308016 A 19870910

Priority

  • US 90641386 A 19860911
  • US 93287186 A 19861118

Abstract (en)

[origin: EP0260880A2] The invention provides a method of turning on the cytolytic effector function of human cytolytic T-cells or human natural killer cells, the method involving contacting the cells with a substance or mixture of substances characterized in that the substance or the mixtures binds specifically to the T11 sheep erythrocyte binding glycoprotein of the cells and is capable upon the binding of turning on the cytolytic effector function. Also provided is a cDNA sequence encoding human T11 or a fragment thereof which is capable of inhibiting T-lymphocyte activation.

IPC 1-7

A61K 35/12; A61K 39/395; C12N 15/00; C12P 21/00

IPC 8 full level

C07K 14/705 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C07K 14/70507 (2013.01); C07K 16/2806 (2013.01); A61K 38/00 (2013.01); C07K 2317/34 (2013.01)

Citation (search report)

  • [X] US 4381292 A 19830426 - BIEBER CHARLES P, et al
  • Nature, Vol. 317, October 3, 1985, pages 428-430; R.F. SILICIANO et al.: "Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein", whole article.
  • Journal of Immunology, Vol. 136, No. 6, March 15, 1986, pages 1945-1950; Am. Ass. Imm., US, D.A. FOX et al.: "Regulation of the alternative pathway of T cell activation by anti-T3 monoclonal antibody", wh9ole article.
  • Proc. Natl. Acad. Sci. USA, Vol. 81, November 1984, Immunology, pages 6836-6840; US, M.J. WEISS et al.: "Calcium dependency of antigen-specific (T3-Ti) and alternative (T11) pathways of human T-cell activation", page 6838, column 1, lines 21-42.
  • CHEMICAL ABSTRACTS, Vol. 105, No. 21, November 24, 1986, page 559, Ref. No. 189067c; Columbus, Ohio, US, D. OLIVE et al.: "Anti-CD2 (sheep red blood cell receptor) monoclonal antibodies and T cell activation. I. Pairs of anti-T11.1 and T11.2 (CD2 subgroups) are strongly mitogenic for T cells in presence of 12-O-tetradecanoylphorbol 13-acetate", & Eur. J. Immunol. 1986, 16(9), 1063-8, Abstract.
  • CHEMICAL ABSTRACTS, Vol. 105, No. 13, September 29, 1986, page 219, Ref. No. 109931s; Columbus, Ohio, US, W.A. SEWELL et al.: "Molecular cloning of the human T lymphocyte surface CD2(T11) antigen", & Biochem. Soc. Trans. 1986, 14(6), 1009, Abstract.
  • Scand. J. Immunol., Vol. 23, 1986, pages 535-544; G. LECA et al.: "The sheep erythrocyte receptor and both alpha and beta chains of the human T-lymphocyte antigen receptor bind to mitogenic lectin (phytohaemagglutinin) from Phaseolus vulgaris", page 541, column 2, lines 18-32, figure 5.
  • Proc. Natl. Acad. Sci. USA, Vol. 83, November 1986, Immunology, pages 8718-8722; US, W.A. SEWELL et al.: "Molecular cloning of the human T-lymphocyte surface CD2(T11) antigen", whole article.
  • Eur. J. Immunol., Vol. 17, 1987, pages 15-20; VCH Verlags GmbH, Weinheim, DE, M.H. BROWN et al.: "Purification and N-terminal amino acid sequence of the human T lymphocyte CD2(T11) surface antigen", whole article.
  • Proc. Natl. Acad. Sci. USA, Vol. 84, May 1987, Immunology, pages 2941-2945; US, P.H. SAYRE et al.: "Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes", whole article.

Designated contracting state (EPC)

BE DE FR GB IT NL SE

DOCDB simple family (publication)

EP 0260880 A2 19880323; EP 0260880 A3 19900307; DE 260880 T1 19881103

DOCDB simple family (application)

EP 87308016 A 19870910; DE 87308016 T 19870910