Global Patent Index - EP 0267952 A4

EP 0267952 A4 19890627 - FECAL OCCULT BLOOD TEST REAGENTS AND METHODS.

Title (en)

FECAL OCCULT BLOOD TEST REAGENTS AND METHODS.

Title (de)

TESTREAGENZIEN UND VERFAREN ZUR BESTIMMUNG VON OKKULTEM BLUT IN FÄKALIEN.

Title (fr)

REACTIFS DE TEST ET PROCEDES PERMETTANT DE DECELER LA PRESENCE DE SANG DANS LES FECES.

Publication

EP 0267952 A4 19890627 (EN)

Application

EP 87903812 A 19870601

Priority

US 86957386 A 19860602

Abstract (en)

[origin: WO8707718A1] Fecal occult blood tests of enhanced sensitivity, specificity, and readability are provided by employing a developer or complete reagent solution that uses as a solvent system a solvent comprising at least about 50 % by volume of a solvent for iron protoporphyrins. In a preferred embodiment, the solvent for iron protoporphyrins comprises a mixture of a neutralized amine and an organic co-solvent. Alternatively, the solvent may comprise pyridine, an amide, a sulfoxide or sulfone, or mixtures thereof. Test results may be improved by incorporating hemoprotein solubilizing agents, plant peroxidase inhibitors, iron/copper chelating agents, accelerators and buffers in the developer/reagent.

IPC 1-7

G01N 21/78; G01N 33/72

IPC 8 full level

C12Q 1/28 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP)

C12Q 1/28 (2013.01)

Citation (search report)

  • [X] US 4017261 A 19770412 - SVOBODA VLASTIMIL, et al
  • [Y] US 4578358 A 19860325 - OKSMAN NORMAN H [US], et al
  • [Y] EP 0064392 A1 19821110 - SMITH KLINE INSTR [US]
  • [X] EP 0021407 A1 19810107 - BEHRINGWERKE AG [DE]
  • [Y] CHEMICAL ABSTRACTS, vol. 103, 1985, page 381, abstract no. 76969p, Columbus, Ohio, US; M.B. BEREZIN et al.: "Dissolution and solvation of protoporphyrin-group porphyrins in organic solvents", & IZV. VYSSH. UCHEBN. ZAVED., KHIM. KHIM. TEKHNOL. 1985, 28(3), 41-5
  • [Y] CLINICAL CHEMISTRY, vol. 29, no. 12, December 1983, pages 2061-2067, Washington, US; S. SCHWARTZ et al.: "The 'HemoQuant' test: a specific and quantitative determination of heme (hemoglobin) in feces and other materials"
  • See references of WO 8707718A1

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 8707718 A1 19871217; EP 0267952 A1 19880525; EP 0267952 A4 19890627; JP H087208 B2 19960129; JP S63503483 A 19881215

DOCDB simple family (application)

US 8701271 W 19870601; EP 87903812 A 19870601; JP 50353287 A 19870601