EP 0273401 B1 19921111 - ISOINDOLIN-1-ONE DERIVATIVE AND ANTIARRHYTHMIC AGENT
Title (en)
ISOINDOLIN-1-ONE DERIVATIVE AND ANTIARRHYTHMIC AGENT
Publication
Application
Priority
JP 30780286 A 19861225
Abstract (en)
[origin: EP0273401A1] Isoindolin-1-one compounds represented by the following formula (I); <CHEM> {wherein n represents an integer of 1 to 6; m represents 0 or 1; R1, R2 and R3 are each independently hydrogen or lower alkyl, and when m is 1, R1 and one of R2 and R3 may form a five-membered or six-membered ring over N atom; X represents hydrogen or hydroxy; Ar represents naphthyl, pyridyl or substituted phenyl represented by the formula (II); Ar and X may form a lactone ring; <CHEM> [wherein Y represents carboxyl, lower alkoxycarbonyl, carbamoyl, N,N-lower alkyl-substituted carbamoyl or amino represented by the formula (III): <CHEM> (wherein R6 and R7 are each independently hydrogen, lower alkyl or lower alkanoyl); R4 and R5 are each independently hydrogen, lower alkyl, cyano or halogen]} or a pharmaceutically acceptable acid addition salt or metal salt thereof have an excellent antiarrhythmic activity.
IPC 1-7
A61K 31/40; A61K 31/44; C07D 209/44; C07D 401/04; C07D 403/06
IPC 8 full level
C07D 209/46 (2006.01); C07D 209/48 (2006.01); C07D 401/04 (2006.01); C07D 491/10 (2006.01)
CPC (source: EP US)
C07D 209/46 (2013.01 - EP US); C07D 209/48 (2013.01 - EP US); C07D 401/04 (2013.01 - EP US); C07D 491/10 (2013.01 - EP US)
Designated contracting state (EPC)
DE FR GB IT
DOCDB simple family (publication)
EP 0273401 A1 19880706; EP 0273401 B1 19921111; CA 1284647 C 19910604; DE 3782636 D1 19921217; DE 3782636 T2 19930408; US 4849441 A 19890718
DOCDB simple family (application)
EP 87119167 A 19871223; CA 555154 A 19871222; DE 3782636 T 19871223; US 13685587 A 19871222