EP 0275305 A4 19881107 - DNA SEQUENCES CODING FOR MODIFIED FACTOR VIII:C AND MODIFIED FACTOR VIII:C-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THESE POLYPEPTIDES IN HIGH YIELDS.
Title (en)
DNA SEQUENCES CODING FOR MODIFIED FACTOR VIII:C AND MODIFIED FACTOR VIII:C-LIKE POLYPEPTIDES AND PROCESSES FOR PRODUCING THESE POLYPEPTIDES IN HIGH YIELDS.
Title (de)
DNA-SEQUENZEN, DIE FÜR EINEN MODIFIZIERTEN FAKTOR-VIII:C KODIEREN, MODIFIZIERTE DEM FAKTOR-VIII:C ÄHNLICHE POLYPEPTIDE UND VERFAHREN ZUR HERSTELLUNG DIESER POLYPEPTIDE IN GROSSEN MENGEN.
Title (fr)
SEQUENCES ADN POUR FACTEUR VIII:C MODIFIE ET POLYPEPTIDES SEMBLABLES AU FACTEUR VIII:C MODIFIE ET PROCEDES DE PRODUCTION EN GRANDES QUANTITES DE CES POLYPEPTIDES.
Publication
Application
Priority
US 89337586 A 19860801
Abstract (en)
[origin: WO8800831A1] DNA sequences coding on expression for modified factor VIII:C and modified factor VIII:C-like polypeptides and methods of making them in high yields in appropriate hosts transformed with those DNA sequences. DNA sequences containing internal deletions removing a major part of the sequence which codes on expression for the maturation polypeptide of factor VIII:C express modified factor VIII:C and modified factor VIII:C-like polypeptides 20 times more efficiently than DNA sequences coding for the factor VIII:C.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/46 (2006.01); A61P 7/02 (2006.01); A61P 7/04 (2006.01); C07H 21/04 (2006.01); C07K 14/00 (2006.01); C07K 14/745 (2006.01); C07K 14/755 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12P 21/02 (2006.01); D04B 9/42 (2006.01); C12R 1/19 (2006.01)
CPC (source: EP KR)
A61K 35/14 (2013.01 - KR); A61P 7/02 (2017.12 - EP); A61P 7/04 (2017.12 - EP); C07K 14/755 (2013.01 - EP); C12N 15/85 (2013.01 - EP); A61K 38/00 (2013.01 - EP)
Citation (search report)
- EP 0123945 A1 19841107 - SCRIPPS CLINIC RES [US]
- EP 0150735 A2 19850807 - CHIRON CORP [US], et al
- EP 0182372 A2 19860528 - SCRIPPS CLINIC RES [US]
- EP 0197901 A1 19861015 - KABIVITRUM AB [SE]
- WO 8800210 A1 19880114 - NORDISK GENTOFTE [DK]
- WO 8707144 A1 19871203 - GENETICS INST [US]
- EP 0265778 A1 19880504 - RORER INT OVERSEAS [US]
- EP 0253455 A1 19880120 - GIST BROCADES NV [NL]
- Biochemistry, Vol. 25, No. 26, December 30, 1986, pages 8343-8347; Am. Chem. Soc., Washington, US; D.L. EATON et al.: "Construction and characterization offan active factor VIII variant lacking the central one-third of the molecule",,whole article.
- See references of WO 8800831A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8800831 A1 19880211; AU 595640 B2 19900405; AU 7804087 A 19880224; EP 0275305 A1 19880727; EP 0275305 A4 19881107; JP 2525438 B2 19960821; JP S63503275 A 19881202; KR 880701557 A 19881103; KR 910006424 B1 19910824
DOCDB simple family (application)
US 8701814 W 19870731; AU 7804087 A 19870731; EP 87905356 A 19870731; JP 50481287 A 19870731; KR 880700355 A 19880401