Global Patent Index - EP 0279705 A3

EP 0279705 A3 19891123 - SCREENING BODY FLUIDS FOR SUPEROXIDE DISMUTASE (SOD-1) FOR DETERMINING FETAL TRISOMY 21 DOWN SYNDROME, AND ANTIBODIES, HYBRIDOMAS AND KITS THEREFOR

Title (en)

SCREENING BODY FLUIDS FOR SUPEROXIDE DISMUTASE (SOD-1) FOR DETERMINING FETAL TRISOMY 21 DOWN SYNDROME, AND ANTIBODIES, HYBRIDOMAS AND KITS THEREFOR

Publication

EP 0279705 A3 19891123 (EN)

Application

EP 88301455 A 19880219

Priority

US 1715287 A 19870220

Abstract (en)

[origin: EP0279705A2] Disclosed is a screening assay for determining the amount of Superoxide Dismutase (SOD-1) in extra-cellular body fluids, for use in determining Trisomy 21 Down syndrome in a fetus. The assay can be done by any of a number of well known techniques including Radio-immunoassay, an Enzyme Linked Immunoassay, or a luminescence assay, single or tandem antibody type, carried out in solid or liquid phase. Polyclonal or monoclonal antibodies can be used. In the preferred embodiment, the assay is used to determine SOD-1 levels in amniotic fluid. A level above a threshold indicates a high probability of Trisomy 21 Down Syndrome for the fetus.

IPC 1-7

G01N 33/573; G01N 33/577; C12P 21/00; C12N 5/00

IPC 8 full level

G01N 33/53 (2006.01); C07K 16/40 (2006.01)

CPC (source: EP US)

C07K 16/40 (2013.01 - EP US); Y10S 436/811 (2013.01 - EP US)

Citation (search report)

  • [XP] EP 0217542 A1 19870408 - UBE INDUSTRIES [JP]
  • [A] GB 2089980 A 19820630 - TOYO JOZO KK
  • [A] FR 2593289 A1 19870724 - BARET ALAIN [FR]
  • [XD] ACTA POEDIATRICA SKANDINAVIA, vol. 74, no. 55, 1985, pages 697-700, Almquist Wiksel Periodicals Co., Stockholm, SE; M.A. BAETEMAN et al.: "Immunoreactive SOD-1 in amniotic fluid, amniotic cells and fibroblasts from trisomy 21 fetus"
  • [XP] CLINICA CHIMICA ACTA, vol. 171, no. 1, 15th January 1988, pages 1-11, Elsevier Science Publishers B.V., Amsterdam, NL; T. PORSTMANN et al.: "A rapid and sensitive enzyme immunoassay for Cu/Zn superoxide dismutase with polyclonal and monoclonal antibodies"
  • [A] PATENT ABSTRACTS OF JAPAN, vol. 7, no. 78 (P-188)[1223], 31st March 1983; & JP-A-58 007 560 (MAMORU SUGIURA) 17-01-1983
  • [X] CHEMICAL ABSTRACTS, vol. 103, no. 21, 25th November 1985, page 560, abstract no. 176901d, Columbus, Ohio, US; & JP-A-60 109 528 (FUJISAWA PHARMACEUTICAL CO. LTD) 15-06-1985
  • [AP] CLINICAL GENETICS, vol. 33, no. 1, January 1988, pages 11-19, Munksgaard International Publishers, Copenhagen, DK; A. JEZIOROWSKA et al.: "Regular trisomy 21 not accompanied by increased copper-zinc superoxide dismutase (SOD1) activity"
  • [AP] HUMAN GENETICS, vol. 75, no. 3, 1987, pages 251-257, Springer Verlag, Heidelberg, DE; J.L. HURET et al.: "Down syndrome with duplication of a region of chromosome 21 containing the CuZn superoxide dismutase gene without detectable karyotypic abnormality"

Designated contracting state (EPC)

AT BE CH DE ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0279705 A2 19880824; EP 0279705 A3 19891123; AU 1196288 A 19880825; JP S63298060 A 19881205; US 4940659 A 19900710

DOCDB simple family (application)

EP 88301455 A 19880219; AU 1196288 A 19880219; JP 3844588 A 19880220; US 1715287 A 19870220