EP 0281579 A4 19890119 - COFACTOR OF PROUROKINASE.
Title (en)
COFACTOR OF PROUROKINASE.
Title (de)
CO-FAKTOR FÜR PROUROKINASE.
Title (fr)
CO-FACTEUR DE PROUROKINASE.
Publication
Application
Priority
- US 883787 A 19870130
- US 89588486 A 19860812
Abstract (en)
[origin: WO8801175A1] A method of increasing the efficacy of pro-UK-induced thrombolysis in a human patient to whom pro-UK is administered, the method involving administering to the patient, in addition to the pro-UK, a cofactor of pro-UK and UK, the cofactor being characterized in that a) it has a molecular weight of about 50,000; b) it increases the affinity of pro-UK for fibrin; c) it confers, on the UK generated from pro-UK, affinity for fibrin; and d) it confers, on the UK generated from pro-UK, thrombolytic activity which is fibrin-dependent.
IPC 1-7
IPC 8 full level
A61K 35/16 (2015.01); A61K 35/22 (2015.01); A61K 38/49 (2006.01)
CPC (source: EP)
A61K 35/16 (2013.01); A61K 35/22 (2013.01); A61K 38/49 (2013.01)
C-Set (source: EP)
Citation (search report)
- [Y] EP 0181596 A2 19860521 - TERUMO CORP [JP]
- [Y] WO 8603973 A1 19860717 - TERUMO CORP [JP]
- [Y] CHEMICAL ABSTRACTS, vol. 105, 1986, page 263, abstract no. 2687q, Columbus, Ohio, US; R. PANNELL et al.: "Pro-urokinase: a study of its stability in plasma and of a mechanism for its selective fibrinolytic effect", & BLOOD, 1986, 67(5), 1215-23
- See references of WO 8801175A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8801175 A1 19880225; EP 0281579 A1 19880914; EP 0281579 A4 19890119
DOCDB simple family (application)
US 8701945 W 19870811; EP 87905410 A 19870811