Global Patent Index - EP 0287328 A3

EP 0287328 A3 19891206 - PREPARATION OF CHROMOGENIC CRYPTAHEMISPHERANDS

Title (en)

PREPARATION OF CHROMOGENIC CRYPTAHEMISPHERANDS

Publication

EP 0287328 A3 19891206 (EN)

Application

EP 88303274 A 19880412

Priority

US 3868087 A 19870415

Abstract (en)

[origin: EP0287328A2] A process for the preparation of a chromogenic cryptahemispherand (I) having the structure <CHEM> said process comprising the steps of: (a) coupling a compound (II) having the structure <CHEM> with a compound (III) having the structure <CHEM> to form a compound (IV) having the structure <CHEM> (b) subjecting the compound (IV) to reducing conditions to form a compound (V) having the structure <CHEM> (c) coupling the compound (V) to a compound having the structure <CHEM> to form a compound (VI) having the structure <CHEM> (d) halogenating the compound (VI) to form a compound (VII) having the structure <CHEM> (e) forming the chromogenic cryptahemispherand (I) by coupling the compound (VII) with a diazacorand having the structure <CHEM> wherein each R is independently hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl, or benzyl; each R'' is independently lower alkyl, lower alkylidene, lower alkenyl, allyl, aryl, or benzyl; each R'' is independently hydrogen, lower alkyl, lower alkylidene, lower alkenyl, aryl or benzyl; each Y is independently an electron withdrawing group; each Z is halogen, a is 1 to about 3; b is 1 to about 3; k is 1 to about 3; l is 1 to about 3; m is 1 to about 3; n is 1 to about 3; and x is 2 to 4.

IPC 1-7

C07D 498/08

IPC 8 full level

G01N 31/00 (2006.01); C07D 498/08 (2006.01); C09B 57/00 (2006.01); G01N 31/22 (2006.01); G01N 33/84 (2006.01)

CPC (source: EP)

C07D 498/08 (2013.01)

Citation (search report)

  • [A] EP 0085320 A2 19830810 - MERCK PATENT GMBH [DE]
  • [A] US 4156683 A 19790529 - LEHN JEAN-MARIE [FR]
  • [AP] EP 0223613 A2 19870527 - AMERSHAM INT PLC [GB]
  • [A] JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 108, 1986 CRAM et al. "Host-quest complexation. 38. Cytohemis- pherands and their complexes" pages 2989-2998
  • [XD] THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 64, 1942 BLOCK et al. "The Synthesis of 3',5'-Xiiodothyronine" pages 1070-1074
  • [A] SYNTHETIC COMMUNICATIONS, vol. 11 (7), 1981 MIYAURA et al. "The palladium-catalyzed cross- -coupling reaction of phenyl- boronic acid with haloarenes in the presence of bases" pages 513-519

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL SE

DOCDB simple family (publication)

EP 0287328 A2 19881019; EP 0287328 A3 19891206; EP 0287328 B1 19931006; AU 1142588 A 19881020; AU 599544 B2 19900719; CA 1316174 C 19930413; DE 3884654 D1 19931111; DE 3884654 T2 19940203; DK 203888 A 19890106; DK 203888 D0 19880414; ES 2059510 T3 19941116; IL 84422 A0 19880429; IL 84422 A 19930315; JP 2603093 B2 19970423; JP S63268770 A 19881107

DOCDB simple family (application)

EP 88303274 A 19880412; AU 1142588 A 19880208; CA 557466 A 19880127; DE 3884654 T 19880412; DK 203888 A 19880414; ES 88303274 T 19880412; IL 8442287 A 19871110; JP 3103588 A 19880215