Global Patent Index - EP 0294307 A1

EP 0294307 A1 19881207 - 3-Arylcarbamoyl-5-aminomethyl-oxazolidines, and their salts with pharmaceutically acceptable acids.

Title (en)

3-Arylcarbamoyl-5-aminomethyl-oxazolidines, and their salts with pharmaceutically acceptable acids.

Title (de)

3-Arylcarbamoyl-5-aminomethyl-oxazolidine sowie deren Salz mit pharmakologisch verträglichen Säuren.

Title (fr)

Arylcarbamoyl-3 aminométhyl-5 oxazolidines ainsi que leurs sels avec des acides pharmacologiquement compatibles.

Publication

EP 0294307 A1 19881207 (FR)

Application

EP 88450019 A 19880509

Priority

  • FR 8706890 A 19870514
  • FR 8806253 A 19880505

Abstract (en)

The compounds of the invention have the general formula of the structure <IMAGE> The group R1 is an oxygen or an NH group, the group R2 is an oxygen or a sulphur, the group Ar1 is a phenyl group optionally substituted by one or more groups chosen from C1-C4 lower alkyl groups, halogen chlorine bromine fluorine, a trifluoromethyl group or a methoxy group, the group Ar1 may also be a pyridyl group or a pyrimidyl group, the group Ar2 is a phenyl group optionally substituted by one or more groups chosen from optionally lower alkyl groups by one or more groups chosen from C1-C4 lower alkyl groups, halogen chlorine bromine fluorine iodine. The compounds of the invention are useful in the treatment of hypertension and of candidiasis.

IPC 1-7

A61K 31/495; C07D 263/26; C07D 263/28; C07D 413/12

IPC 8 full level

C07D 263/26 (2006.01); C07D 263/28 (2006.01); C07D 413/12 (2006.01)

CPC (source: EP)

C07D 263/26 (2013.01); C07D 263/28 (2013.01); C07D 413/12 (2013.01)

Citation (search report)

  • [A] GB 2059961 A 19810429 - NIPPON SODA CO
  • [AD] EP 0105821 A1 19840418 - CORTIAL [FR]
  • [A] FR 2226165 A2 19741115 - DELALANDE SA [FR]
  • [AD] CHEMICAL ABSTRACTS, vol. 91, no. 25, 17 décembre 1979, page 676, résumé no. 211309z, Columbus, Ohio, US; Y. YAMAMOTO et al.: "Studies on thiazoline derivatives. XV. Reactions of 2-phenyl and 2-methylamino-2-thiazolines with methyl and phenylisothiocyanates", & KYORITSU YAKKA DAIGAKU KENKYU NEMPO 1978, (23), 38-46

Designated contracting state (EPC)

AT BE CH DE ES GB IT LI LU NL

DOCDB simple family (publication)

EP 0294307 A1 19881207; EP 0294307 B1 19940622; AT E107637 T1 19940715; DE 3850304 D1 19940728; DE 3850304 T2 19941027; ES 2056121 T3 19941001; FR 2631029 A2 19891110; FR 2631029 B2 19910405

DOCDB simple family (application)

EP 88450019 A 19880509; AT 88450019 T 19880509; DE 3850304 T 19880509; ES 88450019 T 19880509; FR 8806253 A 19880505