Global Patent Index - EP 0294380 A4

EP 0294380 A4 19900220 - STIMULATION OF ANGIOGENESIS.

Title (en)

STIMULATION OF ANGIOGENESIS.

Title (de)

STIMULIERUNG VON ANGIOGENESE.

Title (fr)

STIMULATION DE L'ANGIOGENESE.

Publication

EP 0294380 A4 19900220 (EN)

Application

EP 87901278 A 19870210

Priority

AU PH466886 A 19860218

Abstract (en)

[origin: WO8704925A1] Method for stimulating angiogenesis in a mammal, characterized by the use of a modulator of collagen sysnthesis or of collagen fibril assembly. Preferably the modulator is an inhibitor of the enzyme proline hydroxylase. Preferably the modulator is selected from the group which includes cis-4-hydroxy-L-proline, 3,4-dehydro-L-proline, L-azetidine-2-carboxylic acid, L-proline analogues, and their pharmacologically active analogues and derivatives. The modulator may optionally be used together with a second stimulator of angiogenesis. Compositions containing said modulators are also claimed.

IPC 1-7

A61K 31/195; A61K 31/395; A61K 31/40

IPC 8 full level

A61K 31/19 (2006.01); A61K 31/195 (2006.01); A61K 31/395 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/425 (2006.01); A61K 31/60 (2006.01); A61K 38/18 (2006.01); A61K 45/00 (2006.01); C07D 205/06 (2006.01); C07D 207/00 (2006.01)

CPC (source: EP US)

A61K 31/395 (2013.01 - EP US); A61K 31/40 (2013.01 - EP); A61K 31/425 (2013.01 - EP); A61K 31/60 (2013.01 - EP); A61K 38/1808 (2013.01 - EP)

Citation (search report)

  • Transplantation, Vol. 36, No. 1, 1983, pages 1-6, The Williams & Wilkins Co., A. NEMLANDER et al.: "Effect of cyclosporine on wound healing", whole article.
  • The Journal of Investigative Dermatology, Vol. 80, No. 4, 1983, pages 261-267, The Williams & Wilkins Co., E.M.L. TAN et al.: "Proline analogues inhibit human skin fibroblast growth and collagen production in culture", whole article.
  • Am. J. Pathol., Vol. 106, 1982, pages 180-186, American Association of Pathologists, J.A. MADRI et al.: "Aortic endothelial cell migration", whole article, especially page 184.
  • Am. J. Pathol., Vol. 112, No. 2, 1983, pages 224-230, American Association of Pathologists, I.Y.R. ADAMSON et al.: "Endothelial injury and repair in radiation-induced pulmonary fibrosis", whole article.
  • Experimental and Molecular Pathology, Vol. 39, 1983, pages 219-229, Academic Press Inc., T.M. HERING et al.: "Type V collagen during granulation tissue development", whole article.
  • Cell Biology International Reports, Vol. 9, No. 2, February 1985, pages 175-182, Academic Press Inc., London, GB; B.R. McAUSLAN et al.: "New functions of epidermal growth factor: stimulation of capillary endothelial cell migration and matrix dependent proliferation", whole article.
  • Prog. Microcir. Res. (Proc. Austr. Symp. Microcirc.), 1st edition, 1981, pages 470-482, Ed. D. GARLICH et al., B.R. McAUSLAN et al.: "A new theory of neovascularisation and its relevance to the clinical use of aspirin", whole article.
  • Experimental Cell Research, Vol. 176, 1988, pages 248-257, Academic Press Inc., B.R. McAUSLAN et al.: "Induction of endothelial cell migration by proline analogs and its relevance to angiogenesis", whole article.
  • See references of WO 8704925A1

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 8704925 A1 19870827; EP 0294380 A1 19881214; EP 0294380 A4 19900220; JP S63502661 A 19881006

DOCDB simple family (application)

AU 8700037 W 19870210; EP 87901278 A 19870210; JP 50136087 A 19870210