EP 0302871 A1 19890215 - 1,4-Dihydropyridines.

Title (en)

1,4-Dihydropyridines.

Title (de)

1,4-Dihydropyridine.

Title (fr)

Dérivés de 1,4-Dihydropyridines.

Publication

EP 0302871 A1 19890215 (DE)

Application

EP 87902503 A 19870417

Priority

CH 162386 A 19860422
CH 163386 A 19860422

Abstract (en)

[origin: WO8706579A1] Dihydropyridine of formula (I), in which R6 and R7 represent jointly, and inclusively of the nitrogen atom to which both are bound, a residue of formula (II), wherein A is -CH2-C(R8)R9-CH2-; R8 is aryl and R9 is aryl, whereby aryl stands for a ring of formula (III) in which R10 and R11 are the same or different and signify hydrogen, alkyl, alkoxy, halogen, hydroxy or trifluoromethyl and wherein either E is alkylene, R2 amino and R3 alkyl or alkoxyalkyl, or E is A1-O-A2, R2 is hydrogen, alkyl or alkoxyalkyl and R3 is hydrogen, alkyl or alkoxyalkyl, whereby A1 is alkylene and A2 alkylene or alkyleneoxy-alkylene, and the salts of these compounds, as well as process for their production and their use as medicaments.

Abstract (fr)

Dihydropyridine de formule (I) dans laquelle R6 et R7 représentent conjointement, et y compris l'atome d'azote auquel ils sont tous deux liés, un résidu de formule (II), dans laquelle A est -CH2-C(R8)R9-CH2-; R8 est aryle et R9 est aryle, aryle représentant un composé cyclique de formule (III) dans laquelle R10 et R11 sont identiques ou différents et sont hydrogène, alkyle, alkoxy, halogène, hydroxy ou trifluorométhyle, et où soit E est alkylène, R2 amino et R3 alkyle ou alkoxyalkyle, soit E est A1-0-A2, R2 est hydrogène, alkyle ou alkoxyalkyle et R3 est hydrogène, alkyle ou alkoxyalkyle, A1 étant alkylène et A2 étant alkylène ou alkylèneoxy-alkylène. Sont également décrits les sels de ces composés, ainsi qu'un procédé pour leur production et leur utilisation comme médicaments.

IPC 1-7

A61K 31/44; C07D 211/90; C07D 405/14; C07D 409/14; C07D 413/14; C07D 417/14

IPC 8 full level

A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/445 (2006.01); A61K 31/455 (2006.01); A61P 3/00 (2006.01); A61P 7/02 (2006.01); A61P 9/08 (2006.01); A61P 9/12 (2006.01); C07D 211/00 (2006.01); C07D 211/90 (2006.01); C07D 401/00 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 405/00 (2006.01); C07D 405/04 (2006.01); C07D 409/00 (2006.01); C07D 409/14 (2006.01); C07D 413/00 (2006.01); C07D 413/14 (2006.01)

CPC (source: EP US)

A61P 3/00 (2017.12 - EP); A61P 7/02 (2017.12 - EP); A61P 9/08 (2017.12 - EP); A61P 9/12 (2017.12 - EP); C07D 211/90 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 413/14 (2013.01 - EP US)

Citation (search report)

See references of WO 8706579A1

Designated contracting state (EPC)

AT BE CH DE ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0242829 A1 19871028; AU 7390187 A 19871124; EP 0302871 A1 19890215; IL 82294 A0 19871030; IL 82294 A 19911121; JP H01500118 A 19890119; NZ 220022 A 19900426; PT 84732 A 19870501; PT 84732 B 19891229; US 5064839 A 19911112; WO 8706579 A1 19871105

DOCDB simple family (application)

EP 87105748 A 19870417; AU 7390187 A 19870417; EP 8700210 W 19870417; EP 87902503 A 19870417; IL 8229487 A 19870422; JP 50295187 A 19870417; NZ 22002287 A 19870416; PT 8473287 A 19870422; US 27277588 A 19881021