EP 0314444 A3 19901107 - NOVEL OXATHIOLANES AND DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE THEREOF AS MEDICAMENTS
Title (en)
NOVEL OXATHIOLANES AND DERIVATIVES THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE THEREOF AS MEDICAMENTS
Publication
Application
Priority
- US 11447387 A 19871028
- US 18921088 A 19880502
Abstract (en)
[origin: EP0314444A2] Novel spiro-oxathiolane/quinuclidine compounds correspond with the schematic structural formula (I) <CHEM> and geometrical isomers, enantiomers, diastereoisomers, racemates and acid addition salts thereof, wherein one of Y and Z is O and the other is S (=O)n; n is 0, 1 or 2; R min and R sec are each selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, aminoalkyl, C3-7 cycloalkyl, aryl, diarylmethylol and alkyl substituted by at least one aryl group, provided that at least R min or R sec is other than hydrogen; and each X is hydrogen, or when Y is O and Z is S(=O)n simultaneously, then each X may also be selected from the group consisting of deuterium and tritium, and provided further that when each X is hydrogen, Y is O and Z is S simultaneously, then at least one of R min and R sec is selected from the group consisting of alkenyl, alkynyl, cyclopropyl, cyclobutyl, cycloheptyl, hydroxyalkyl and aminoalkyl. These compounds are useful for manufacturing therapeutic and diagnostic agents applicable to disorders of or relating to the central nervous and cholinergic systems.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61K 38/04 (2006.01); A61P 25/00 (2006.01); A61P 25/02 (2006.01); A61P 25/28 (2006.01); C07D 497/20 (2006.01)
CPC (source: EP KR US)
A61P 25/00 (2018.01 - EP); A61P 25/02 (2018.01 - EP); A61P 25/28 (2018.01 - EP); C07D 453/00 (2013.01 - KR); C07D 497/20 (2013.01 - EP KR US)
Citation (search report)
- [XD] EP 0205247 A2 19861217 - ISRAEL STATE [IL]
- [A] FR 2146962 A1 19730309 - YOSHITOMI PHARMACEUTICAL [JP]
- [A] FR 2331343 A1 19770610 - MUNDIPHARMA AG [CH]
Designated contracting state (EPC)
AT BE CH DE ES FR GB IT LI LU NL SE
DOCDB simple family (publication)
EP 0314444 A2 19890503; EP 0314444 A3 19901107; EP 0314444 B1 19960529; AT E138663 T1 19960615; AU 2367188 A 19890504; AU 608903 B2 19910418; CA 1315791 C 19930406; DE 3855325 D1 19960704; DE 3855325 T2 19961010; DK 175064 B1 20040517; DK 598688 A 19890429; DK 598688 D0 19881027; ES 2087854 T3 19960801; IL 87834 A0 19890331; IL 87834 A 19920525; JP 2753280 B2 19980518; JP H0262883 A 19900302; KR 890006641 A 19890615; KR 910007979 B1 19911005; NO 167806 B 19910902; NO 167806 C 19911211; NO 884790 D0 19881027; NO 884790 L 19890502; NZ 226415 A 19900528; US 4876260 A 19891024
DOCDB simple family (application)
EP 88310040 A 19881026; AT 88310040 T 19881026; AU 2367188 A 19881012; CA 581526 A 19881027; DE 3855325 T 19881026; DK 598688 A 19881027; ES 88310040 T 19881026; IL 8783488 A 19880922; JP 27108588 A 19881028; KR 880014136 A 19881028; NO 884790 A 19881027; NZ 22641588 A 19880930; US 18921088 A 19880502