EP 0316345 A4 19890516 - LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE.
Title (en)
LIPOSOMES WITH ENHANCED RETENTION ON MUCOSAL TISSUE.
Title (de)
LIPOSOME MIT VERBESSERTER BINDUNG AN SCHLEIMGEWEBE.
Title (fr)
LIPOSOMES A RETENTION AMELIOREE SUR DU TISSU MUQUEUX.
Publication
Application
Priority
- US 89081586 A 19860728
- US 89081786 A 19860728
Abstract (en)
[origin: WO8800824A1] A liposome composition designed for enhanced binding to mucosal tissue. The liposomes contain about 10-40 mole percent of an amine-derivatized lipid component in which a charged amine group is spaced from a lipid polar head region by a carbon-containing spacer arm at least 3 atoms in length. The liposomes preferably have a close packed lipid structure produced by inclusion of between of between 20-50 mole percent of cholesterol or an amine-derivatized cholesterol, and/or phospholipids with predominantly saturated acyl chain moieties. For ophthalmic use, the liposomes may be suspended in an aqueous medium containing a high-viscosity polymer, to enhance further the retention of liposomes on a corneal surface.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01)
CPC (source: EP)
A61K 9/1271 (2013.01)
Citation (search report)
- [A] WO 8302069 A1 19830623 - UNIV CALIFORNIA [US]
- [A] US 4235792 A 19801125 - HSIA JEN C [CA], et al
- [A] CHEMICAL ABSTRACTS, vol. 101, no. 14, 1st October 1984, page 349, abstract no. 116680e, Columbus, Ohio, US; K. SINGH et al.: "Liposomal ophthalmic drug delivery system. II. Dihydrostreptomycin sulfate", & INT. J. PHARM. 1984 19(3), 263-9
- See references of WO 8800824A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8800824 A1 19880211; EP 0316345 A1 19890524; EP 0316345 A4 19890516; JP H02500360 A 19900208
DOCDB simple family (application)
US 8701833 W 19870728; EP 87905136 A 19870728; JP 50485887 A 19870728