EP 0317376 B2 19960403 - Preparation of a concentrate of high-purity human factor IX and of other plasma proteins

Title (en)

Preparation of a concentrate of high-purity human factor IX and of other plasma proteins

Title (de)

Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat

Title (fr)

Préparation de concentré de facteur IX humain de haute pureté et d'autres protéines plasmatiques

Publication

EP 0317376 B2 19960403 (FR)

Application

EP 88402643 A 19881020

Priority

FR 8714665 A 19871023
FR 8806923 A 19880525

Abstract (en)

[origin: EP0317376A1] Process for the preparation of concentrated, high purity factor IX. The concentrate according to the invention is obtained by chromatographic treatment of a prepurified plasma fraction, combining especially anion exchange chromatography and chromatography on immobilised heparin. This concentrate can be employed for the treatment of haemophilia B. The preparative process according to the invention also makes it possible to obtain concentrates of alpha-antitrypsin, of protein C and S of factors II, VII and X, which are suitable for their therapeutic use. The process also makes it possible to recover albumin, immunoglobulins and antithrombin III.

IPC 1-7

C07K 1/22; C07K 14/435

IPC 8 full level

G01N 33/48 (2006.01); A61K 35/14 (2006.01); A61K 38/43 (2006.01); B01D 15/08 (2006.01); C07K 1/16 (2006.01); C07K 1/18 (2006.01); C07K 1/22 (2006.01); C07K 1/30 (2006.01); C07K 14/00 (2006.01); C07K 14/745 (2006.01); C12N 9/64 (2006.01); G01N 30/88 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP US)

C07K 14/745 (2013.01 - EP US); C12N 9/647 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)

Designated contracting state (EPC)

AT BE CH DE ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0317376 A1 19890524; EP 0317376 B1 19930113; EP 0317376 B2 19960403; DE 3877529 D1 19930225; DE 3877529 T2 19961107; DK 173859 B1 20011231; DK 587788 A 19890424; DK 587788 D0 19881021; ES 2045167 T3 19940116; ES 2045167 T5 19960701; GR 3006910 T3 19930630; GR 3019900 T3 19960831; JP 2768957 B2 19980625; JP H01207239 A 19890821; NO 179997 B 19961021; NO 179997 C 19970129; NO 884688 D0 19881021; NO 884688 L 19890424; US 5457181 A 19951010

DOCDB simple family (application)

EP 88402643 A 19881020; DE 3877529 T 19881020; DK 587788 A 19881021; ES 88402643 T 19881020; GR 930400157 T 19930128; GR 960401282 T 19960513; JP 26700488 A 19881022; NO 884688 A 19881021; US 68310991 A 19910411