EP 0323148 A1 19890705 - Dopamine-beta-hydroxylase inhibitors.
Title (en)
Dopamine-beta-hydroxylase inhibitors.
Title (de)
Dopamine-beta-hydroxylase-Inhibitoren.
Title (fr)
Inhibiteurs de dopamine-bêta-hydroxylase.
Publication
Application
Priority
US 13921787 A 19871229
Abstract (en)
Compounds of formula (I) <CHEM> and pharmaceutically acceptable salts or hydrates thereof are described in which, X is H, F, Cl, Br, I, C1-4alkyl, CN, NO2, SO2NH2, COOH, OH, CHO, C1-4alkoxy, CH2OH, CH2OC1-4alkyl, CF3, C2F5, C3F7, SO2CH3, SO2CF3, or CO2CaH2a+1 wherein a is 1 to 5, or any accessible combination thereof up to 5 substituents; n is 0 to 5; m is 1 to 5; R<1> and R<2> are independently H or C1-4alkyl. These compounds are dopamine- beta -hydroxylase inhibitors. Pharmaceutical compositions are described as are methods of use. Processes for the preparation of these compounds are described.
IPC 1-7
IPC 8 full level
A61K 31/415 (2006.01); A61P 9/12 (2006.01); C07D 233/84 (2006.01); C07D 403/12 (2006.01)
CPC (source: EP US)
A61P 9/12 (2017.12 - EP); C07D 233/84 (2013.01 - EP US)
Citation (search report)
- [A] EP 0244956 A1 19871111 - SMITHKLINE BECKMAN CORP [US]
- [A] EP 0221778 A2 19870513 - SMITHKLINE BECKMAN CORP [US]
- [A] EP 0146228 A1 19850626 - FARMOS OY [FI]
- [A] EP 0125783 A1 19841121 - SMITHKLINE BECKMAN CORP [US]
- [AD] EP 0125033 A1 19841114 - SMITHKLINE BECKMAN CORP [US]
- [AP] EP 0294973 A1 19881214 - SMITHKLINE BECKMAN CORP [US]
- [AP] EP 0284375 A1 19880928 - SMITHKLINE BECKMAN CORP [US]
- [AP] EP 0260814 A1 19880323 - SMITHKLINE BECKMAN CORP [US]
Designated contracting state (EPC)
AT BE CH DE ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
EP 0323148 A1 19890705; AU 2936889 A 19890801; JP H03502690 A 19910620; US 4882348 A 19891121; WO 8906127 A1 19890713; ZA 889709 B 19891227
DOCDB simple family (application)
EP 88312195 A 19881222; AU 2936889 A 19891221; JP 50194589 A 19881221; US 13921787 A 19871229; US 8804577 W 19881221; ZA 889709 A 19881229