EP 0326423 A2 19890802 - Vectors, compounds and methods for expression of a hum adenocarcinoma antigen.
Title (en)
Vectors, compounds and methods for expression of a hum adenocarcinoma antigen.
Title (de)
Vektoren, Zusammensetzungen und Verfahren zur Expression von einem menschlichen Adevoharzimomantigen.
Title (fr)
Vecteurs, composes et procédés d'expression d'un antigène adenocarcinome humain.
Publication
Application
Priority
- US 15025288 A 19880129
- US 18456988 A 19880421
Abstract (en)
The present invention comprises novel recombinant DNA compounds which encode the SIMILAR 40,000 dalton adenocarcinoma antigen recognized by monoclonal antibody KS 1/4. Eukaryotic and prokaryotic expression vectors have been constructed that comprise novel KSA-encoding DNA and drive expression of KSA when transformed into an appropriate host cell. The novel expression vectors can be used to produce KSA derivatives, such as non-glycosylated KSA, and to produce KSA precursors, such as nascent KSA, and to produce subfragments of KSA. The recombinant-produced KSA is useful for the diagnosis, prognosis and treatment of disease states including adenocarcinomas of the lung, prostate, breast, ovary and colon/rectum; and for the creation of novel antibodies for treatment or diagnosis of the above.
IPC 1-7
IPC 8 full level
C12P 21/02 (2006.01); C07K 14/705 (2006.01); C07K 14/82 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP US)
C07K 14/705 (2013.01 - EP US); C07K 14/82 (2013.01 - EP US)
Designated contracting state (EPC)
BE CH DE FR GB IT LI NL SE
DOCDB simple family (publication)
EP 0326423 A2 19890802; EP 0326423 A3 19891018; EP 0326423 B1 19950524; CA 1340221 C 19981215; DE 68922757 D1 19950629; DE 68922757 T2 19951116; DK 35189 A 19890731; DK 35189 D0 19890127; IL 89102 A0 19890815; JP 2774298 B2 19980709; JP H025867 A 19900110; US 5348887 A 19940920
DOCDB simple family (application)
EP 89300836 A 19890127; CA 589328 A 19890127; DE 68922757 T 19890127; DK 35189 A 19890127; IL 8910289 A 19890127; JP 2065289 A 19890130; US 97630192 A 19921113