Global Patent Index - EP 0333912 A3

EP 0333912 A3 19900307 - METHOD FOR THE EVAPORATION OF A SAMPLE

Title (en)

METHOD FOR THE EVAPORATION OF A SAMPLE

Publication

EP 0333912 A3 19900307 (DE)

Application

EP 88111565 A 19880719

Priority

DE 3809504 A 19880322

Abstract (en)

[origin: EP0333912A2] During the evaporation of a sample substance consisting of large molecules, in particular for mass spectroscopy investigations, the energy supplied for the evaporation can bring about a thermolytic decomposition of the sample substance. According to the invention, in order to prevent such a decomposition, the sample substance is mixed, before irradiation, with a matrix material which consists of a compound which readily decomposes into gaseous molecules on exposure to the laser beam. This material may be one which absorbs the radiation, readily decomposes thermolytically or, alternatively, is transparent to the laser radiation but is mixed with a metal powder. If the mixture is exposed to laser beam pulses, the unstable matrix material first decomposes and thereby releases the embedded molecules of the sample substance. In particular, in combination with a cooling gas jet, a destruction of the molecules of the sample substance can be avoided almost completely in this way. Suitable compounds for the matrix are, in particular, sugar, cellulose and NH4NO3, and polyethylene with gold or silver dust added.

IPC 1-7

H05H 3/02; H01J 49/14

IPC 8 full level

H05H 3/02 (2006.01)

CPC (source: EP US)

H05H 3/02 (2013.01 - EP US)

Citation (search report)

  • [A] DE 3018455 A1 19801127 - VARIAN MAT GMBH
  • [Y] ANALYTICAL CHEMISTRY, Band 50, Nr. 7, 19. June 1978, Seiten 985-991, American Chemical Society, Columbus, Ohio, US; M.A. POSTHUMUS et al.: "Laser desorption-mass spectrometry of polar nonvolatile bio-organic molecules"
  • [Y] TRAC (TRENDS IN ANALYTICAL CHEMISTRY), Band 6, Nr. 4, April 1987, Seiten 78-81, Elsevier Science Publishers B.V., Amsterdam, NL; R. ISOBE et al.: "Direct microanalysis by negative ion fast atom bombardment mass spectrometry"
  • [A] ANALYTICAL CHEMISTRY, Band 53, Nr. 1, Januar 1981, Seiten 109-113, American Chemical Society, Columbus, Ohio, US; L.K. LIU et al.: "Matrix-assisted secondary ion mass spectra of biological compounds"

Designated contracting state (EPC)

AT BE CH DE ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0333912 A2 19890927; EP 0333912 A3 19900307; EP 0333912 B1 19950628; DE 3809504 C1 19890921; US 5062935 A 19911105

DOCDB simple family (application)

EP 88111565 A 19880719; DE 3809504 A 19880322; US 32676389 A 19890321