EP 0343248 A1 19891129 - NOVEL POLYPEPTIDE AND METHOD FOR PREPARING THE SAME.
Title (en)
NOVEL POLYPEPTIDE AND METHOD FOR PREPARING THE SAME.
Title (de)
POLYPEPTID UND VERFAHREN ZU SEINER HERSTELLUNG.
Title (fr)
NOUVEAU POLYPEPTIDE ET PROCEDE DE PREPRATION.
Publication
Application
Priority
JP 20625887 A 19870821
Abstract (en)
[origin: US5068314A] PCT No. PCT/JP88/00823 Sec. 371 Date Aug. 19, 1989 Sec. 102(e) Date Aug. 19, 1989 PCT Filed Aug. 19, 1988 PCT Pub. No. WO89/01492 PCT Pub. Date Feb. 23, 1989.This invention relates to a novel polypeptide represented by the formula: <IMAGE> (1) (wherein Lys represents lysine, Trp tryptophan, Cys cystine, Phe phenylalanine, Arg arginine, Val valine, Tyr tyrosine, Gly glycine, Ile isoleucine and X a hydroxyl group or an amino group), its analogue and a method for preparing the same. The polypeptide exhibits strong affinity for lipolysaccharide, and is useful for removing endotoxin and as a therapeutic agent of bacterial infections.
Abstract (fr)
Nouveau polypeptide représenté par la formula (I), dans laquelle Lys représente lysine, Trp tryptophane, Cys cystine, Phe phénylalanine, Arg arginine, Val valine, Tyr tyrosine, Gly glycine, Ile isoleucine et X un groupe hydroxyle ou un groupe amino. On décrit également un analogue de ce polypeptide ainsi qu'un procédé de préparation. Ce polypeptide présente une affinité marquée pour le lipopolysaccharide et peut être utilisé pour l'élimination d'endotoxines et en tant qu'agent thérapeutique contre les infections bactériennes.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 1/04 (2006.01); A61P 1/12 (2006.01); A61P 1/16 (2006.01); A61P 17/00 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 37/00 (2006.01); A61P 43/00 (2006.01); C07K 1/02 (2006.01); C07K 1/04 (2006.01); C07K 1/06 (2006.01); C07K 1/113 (2006.01); C07K 1/14 (2006.01); C07K 7/08 (2006.01); C07K 7/64 (2006.01); C07K 14/435 (2006.01); C07K 14/81 (2006.01)
IPC 8 main group level
C07K (2006.01)
CPC (source: EP KR US)
A61P 1/04 (2017.12 - EP); A61P 1/12 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 31/04 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 7/08 (2013.01 - EP KR US); A61K 38/00 (2013.01 - EP US); Y02A 50/30 (2017.12 - EP US)
Citation (search report)
See references of WO 8901492A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
US 5068314 A 19911126; AT E88480 T1 19930515; AU 1702892 A 19920716; AU 2311388 A 19890309; AU 620345 B2 19920220; AU 642089 B2 19931007; CA 1337781 C 19951219; CA 1337782 C 19951219; CN 1031193 C 19960306; CN 1031379 A 19890301; DE 3880481 D1 19930527; DE 3880481 T2 19930909; DK 193589 A 19890616; DK 193589 D0 19890420; EP 0343248 A1 19891129; EP 0343248 B1 19930421; FI 891873 A0 19890419; FI 891873 A 19890419; FI 92708 B 19940915; FI 92708 C 19941227; JP 2710653 B2 19980210; JP H02500194 A 19900125; KR 890701624 A 19891221; KR 970001811 B1 19970215; NO 175372 B 19940627; NO 175372 C 19941005; NO 178663 B 19960129; NO 178663 C 19960508; NO 891572 D0 19890418; NO 891572 L 19890509; NO 940078 D0 19940110; NO 940078 L 19890509; US 5416194 A 19950516; WO 8901492 A1 19890223
DOCDB simple family (application)
US 34848789 A 19890419; AT 88907358 T 19880819; AU 1702892 A 19920520; AU 2311388 A 19880819; CA 575083 A 19880818; CA 616257 A 19911212; CN 88106207 A 19880820; DE 3880481 T 19880819; DK 193589 A 19890420; EP 88907358 A 19880819; FI 891873 A 19890419; JP 50533688 A 19880819; JP 8800823 W 19880819; KR 890700677 A 19890420; NO 891572 A 19890418; NO 940078 A 19940110; US 92696592 A 19920807