EP 0344211 A4 19900312 - MONOCLONAL ANTIBODIES IN VACCINE FORMULATIONS.
Title (en)
MONOCLONAL ANTIBODIES IN VACCINE FORMULATIONS.
Title (de)
MONOKLONALE ANTIKÖRPER IN IMPFSTOFFORMULIERUNGEN.
Title (fr)
ANTICORPS MONOCLONAUX DANS DES COMPOSITIONS DE VACCINS.
Publication
Application
Priority
- US 1680787 A 19870220
- US 15669188 A 19880217
Abstract (en)
[origin: WO8806040A1] Vaccine formulations which provide for active or passive immunity against infection by pathogens. The active component of the vaccines of the present invention comprises a monoclonal antibody or a fragment of the monoclonal antibody which contains the idiotype of the molecule. Vaccine formulations which provide for active immunization of a host against a particular pathogen, are prepared using monoclonal antibodies or idiotypic fragments that bear the conformational image of a specific receptor of the pathogen. Vaccine formulations which provide for passive immunity are prepared from anti-idiotypic antibodies or idiotypic fragments thereof that bear the conformational image of a ligand that binds specifically to a receptor of the pathogen. In either approach, the pathogen is not required to prepare the antibody which comprises the active component of the vaccine formulation.
IPC 1-7
IPC 8 full level
C12N 15/02 (2006.01); A61K 39/395 (2006.01); A61K 39/42 (2006.01); C07K 16/42 (2006.01); C12N 5/10 (2006.01); C12N 5/18 (2006.01); C12N 15/06 (2006.01); C12P 21/08 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61K 39/395 (2013.01); C07K 16/082 (2013.01); C07K 16/4216 (2013.01); C07K 16/4233 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01)
Citation (search report)
- [Y] WO 8601539 A1 19860313 - UNIV COLUMBIA [US]
- [Y] EP 0142345 A2 19850522 - SYNBIOTICS CORP [US]
- [E] WO 8801304 A1 19880225 - UNIV COLUMBIA [US]
- [XP] EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 17, 1987, pages 365-370, Verlagsgesellschaft mbH, Weinheim, DE; G. COLUCCI et al.: "Interactions between hepatitis B virus and polymeric human albumin. I Production of monoclonal anti-idiotypes (anti-anti-polymeric human albumin) which recognize hepatitis B virus surface antigen"
- [XP] EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 17, 1987, pages 371-374, Verlagsgesellschaft mbH, Weinheim, DE; G. COLUCCI et al.: "Interactions between hepatitis B virus and polymeric human serum albumin II. Development of syngeneic monoclonal anti-anti-idiotypes which mimic hepatitis B surface antigen in the induction of immune responsiveness"
- [X] THE JOURNAL OF IMMUNOLOGY, vol. 137, no. 9, 1st November 1986, pages 2937-2944, The American Association of Immunologists, US; J.S. McDOUGAL et al.: "Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody, inhibition, and potential for idiotypic mimicry"
- See also references of WO 8806040A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8806040 A1 19880825; AU 1484688 A 19880914; AU 5217890 A 19900906; EP 0344211 A1 19891206; EP 0344211 A4 19900312; JP H02502183 A 19900719
DOCDB simple family (application)
US 8800512 W 19880219; AU 1484688 A 19880219; AU 5217890 A 19900323; EP 88902682 A 19880219; JP 50263888 A 19880219