EP 0346356 A1 19891220 - SYNTHESIS PROCESS AND OXYGEN-CONTAINING HETEROCYCLIC PRODUCTS THEREOF.
Title (en)
SYNTHESIS PROCESS AND OXYGEN-CONTAINING HETEROCYCLIC PRODUCTS THEREOF.
Title (de)
VERFAHREN ZUR SYNTHESE UND SAUERSTOFF ENTHALTENDE HETEROCYCLISCHE VERBINDUNGEN.
Title (fr)
PROCEDE DE SYNTHESE ET PRODUITS HETEROCYCLIQUES CONTENANT DE L'OXYGENE OBTENUS PAR CE PROCEDE DE SYNTHESE.
Publication
Application
Priority
- US 10813887 A 19871013
- US 10814587 A 19871013
- US 94355586 A 19861218
Abstract (en)
[origin: CH679486A5] A process for synthesizing oxygen-containing analogs of the antimalarial agent known as quinghaosu or artemisinin, and in particular compounds of formulae (I) and (II). The process employs as a reactant a vinylsilane that is subjected to an ozonolysis/acidification step which closes the oxygen-containing ring structure. The various products are claimed as aspects of this invention as is their use as antimalarials.
Abstract (fr)
Procédé de synthèse d'analogues contenant de l'oxygène de l'agent antipaludéen connu sous le nom de quinghaosu ou artémisinine, et en particulier composés de formules (I) et (II). Le procédé utilise comme agent de réaction un vinylsilane qui est soumis à une étape d'ozonolyse/acidification qui ferme la structure de l'anneau contenant l'oxygène. Les divers produits obtenus sont revendiqués ainsi que leur utilisation en tant qu'agent antipaludéen.
IPC 1-7
A61K 31/335; A61K 31/38; A61K 31/395; C07B 59/00; C07D 491/20; C07D 493/04; C07D 493/20; C07D 495/20; C07F 7/08
IPC 8 full level
A61K 31/365 (2006.01); A61K 31/38 (2006.01); A61K 31/435 (2006.01); A61P 33/02 (2006.01); C07D 491/00 (2006.01); C07D 491/18 (2006.01); C07D 493/00 (2006.01); C07D 493/04 (2006.01); C07D 493/18 (2006.01); C07D 495/00 (2006.01); C07D 495/18 (2006.01); C07F 7/08 (2006.01)
CPC (source: EP)
A61P 33/02 (2017.12); C07D 493/04 (2013.01)
Citation (search report)
See references of WO 8804660A2
Designated contracting state (EPC)
FR IT
DOCDB simple family (publication)
WO 8804660 A2 19880630; WO 8804660 A3 19880811; CH 679486 A5 19920228; DE 3790698 T1 19881208; EP 0346356 A1 19891220; GB 2218088 A 19891108; GB 2218088 B 19910710; GB 8818816 D0 19881005; JP H01501710 A 19890615; SE 8802906 D0 19880816; SE 8802906 L 19880816; SE 9000377 D0 19900202; SE 9000377 L 19910803
DOCDB simple family (application)
US 8703330 W 19871215; CH 298688 A 19871215; DE 3790698 T 19871215; EP 88901513 A 19871215; GB 8818816 A 19871215; JP 50174788 A 19871215; SE 8802906 A 19880816; SE 9000377 A 19900202