EP 0347027 B1 19940803 - Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them.
Title (en)
Phenylpyridone derivatives,processes for their preparation and pharmaceutical compositions containing them.
Title (de)
Phenylpyridon-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
Title (fr)
Dérivés de phénylpyridine, procédés pour leur préparation et compositions pharmaceutiques les contenant.
Publication
Application
Priority
GB 8809481 A 19880421
Abstract (en)
[origin: EP0347027A2] Compounds of the formula (1): <CHEM> and pharmaceutically acceptable salts are described, wherein X is O or S; R<1> is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-4alkyl, or C1-4alkyl substituted by 1 to 6 fluoro groups; R<2> is hydrogen, -CN, -CONR<5>R<6>, -CO2R<7>, 5-tetrazolyl, -NO2, -NH2 or -NHCOR<8> wherein R<5>, R<6>, R<7> and R<8> are independently hydrogen or C1-4alkyl; R<3> is hydrogen or C1-4alkyl; and R<4> is hydrogen or C1-4alkyl; with the proviso that R<1> is not methyl when R<2> is -CO2H, -CO2CH2CH3 or -CN, X is 0, R<3> is hydrogen and R<4> is hydrogen or methyl. These compounds have bronchodilator, anti-allergic, vasodilator and anti-inflammatory activities. Pharmaceutical compositions are described as are methods of use. Processes for the preparation of the compounds of the formula (1) are described.
IPC 1-7
C07D 213/85; C07D 213/82; C07D 213/80; C07D 401/04; C07D 213/64; C07D 213/70; C07D 213/73; C07C 49/82; C07C 221/00; A61K 31/44
IPC 8 full level
A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4418 (2006.01); A61K 31/4427 (2006.01); A61P 9/08 (2006.01); A61P 11/08 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07D 213/64 (2006.01); C07D 213/70 (2006.01); C07D 213/73 (2006.01); C07D 213/75 (2006.01); C07D 213/80 (2006.01); C07D 213/82 (2006.01); C07D 213/85 (2006.01); C07D 401/04 (2006.01)
CPC (source: EP)
A61P 9/08 (2017.12); A61P 11/08 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07D 213/64 (2013.01); C07D 213/73 (2013.01); C07D 213/80 (2013.01); C07D 213/82 (2013.01); C07D 213/85 (2013.01); C07D 401/04 (2013.01)
Citation (examination)
- EP 0293063 A1 19881130 - SMITH KLINE FRENCH LAB [GB]
- JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANS I, vol. 10, 1976, pp. 1073-1079
- JOURNAL OF THE CHEMICAL SOCIETY, June 1965, pp. 3610-3613
Designated contracting state (EPC)
AT BE CH DE ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
EP 0347027 A2 19891220; EP 0347027 A3 19900523; EP 0347027 B1 19940803; AT E109470 T1 19940815; AU 3309689 A 19891026; AU 616001 B2 19911017; DE 68917220 D1 19940908; DE 68917220 T2 19941201; DK 194389 A 19891022; DK 194389 D0 19890420; GB 8809481 D0 19880525; JP H01311067 A 19891215; PT 90351 A 19891110; PT 90351 B 19940729; ZA 892898 B 19910130
DOCDB simple family (application)
EP 89303757 A 19890417; AT 89303757 T 19890417; AU 3309689 A 19890417; DE 68917220 T 19890417; DK 194389 A 19890420; GB 8809481 A 19880421; JP 10332389 A 19890421; PT 9035189 A 19890421; ZA 892898 A 19890420