EP 0347163 A2 19891220 - Method for the synthesis of desferrioxamine B and analogs thereof, and intermediates.
Title (en)
Method for the synthesis of desferrioxamine B and analogs thereof, and intermediates.
Title (de)
Verfahren zur Herstellung von Desferrioxamin B und dessen Analogen, und Zwischenprodukte.
Title (fr)
Procédé de préparation de des ferrioxamine B et ses analogues, ainsi que produits intermédiaires.
Publication
Application
Priority
- US 20631988 A 19880614
- US 24615288 A 19880919
- US 35291789 A 19890517
Abstract (en)
Disclosed is a synthesis of desferrioxamine B and analogs and homologs thereof beginning with the generation of the O-protected N-(4-cyanobutyl)hydroxylamine which is acylated at the O-benzylhydroxylamine nitrogen with either succinic or acetic anhydride. The resulting half-acid amide or amide respectively, is subjected to a series of high yield condensations and reductions which provide desferrioxamine B in 45% overall yield. Finally, a desamino analog of desferrioxamine is prepared in order to demonstrate the synthetic utility of the scheme as applied to desferrioxamine derivatives.
IPC 1-7
IPC 8 full level
C07C 251/38 (2006.01); C07C 251/48 (2006.01); C07C 255/64 (2006.01); C07C 259/04 (2006.01); C07C 259/06 (2006.01); C07C 271/60 (2006.01)
CPC (source: EP)
C07C 255/64 (2013.01); C07C 259/06 (2013.01); C07C 271/60 (2013.01)
Designated contracting state (EPC)
BE CH DE ES FR GB GR IT LI NL SE
DOCDB simple family (publication)
EP 0347163 A2 19891220; EP 0347163 A3 19900328; DK 280389 A 19891215; DK 280389 D0 19890608; JP H0334964 A 19910214; PT 90838 A 19891229
DOCDB simple family (application)
EP 89305951 A 19890613; DK 280389 A 19890608; JP 15204489 A 19890614; PT 9083889 A 19890612