EP 0347435 A4 19911121 - DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS
Title (en)
DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS
Publication
Application
Priority
- US 9432287 A 19870904
- US 14164988 A 19880107
Abstract (en)
[origin: WO8901940A1] This invention relates to DNA sequences, recombinant DNA molecules and processes for producing soluble T4 protein. More particularly, this invention relates to DNA sequences that are characterized in that they code on expression in an appropriate unicellular host for soluble forms of T4, the receptor on the surface of T4<+> lymphocytes, or derivatives thereof. In accordance with this invention, the DNA sequences, recombinant DNA molecules and processes of this invention may be employed to produce soluble T4 essentially free of other proteins of human origin. This soluble protein may then advantageously be used in the immunotherapeutic and diagnostic compositions and methods of this invention. The soluble T4-based immunotherapeutic compositions and methods of this invention are useful in treating immunodeficient patients suffering from diseases caused by infective agents whose primary targets are T4<+> lymphocytes. According to a preferred embodiment, this invention relates to soluble T4-based compositions and methods which are useful in preventing, treating or detecting acquired immune deficiency syndrome, AIDS related complex and HIV infection.
IPC 1-7
C07H 15/12; C12Q 1/70; C12Q 1/02; C12Q 1/06; C12P 21/00; C12P 19/34; C12P 1/04; C12N 15/00; C12N 7/00; C07K 13/00
IPC 8 full level
A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61P 37/00 (2006.01); A61P 37/06 (2006.01); C07K 14/00 (2006.01); C07K 14/725 (2006.01); C07K 14/73 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 1/21 (2006.01); C12N 7/02 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); G01N 33/569 (2006.01); C12R 1/19 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP KR)
A61P 37/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); C07H 15/12 (2013.01 - KR); C07K 14/70514 (2013.01 - EP); C07K 16/2812 (2013.01 - EP); C12N 7/00 (2013.01 - EP); G01N 33/56988 (2013.01 - EP); A61K 38/00 (2013.01 - EP); C07K 2317/34 (2013.01 - EP); C12N 2740/15051 (2013.01 - EP)
Citation (search report)
- WO 8801304 A1 19880225 - UNIV COLUMBIA [US]
- WO 8901779 A1 19890309 - GERSHONI JONATHAN M [IL]
- WO 8902922 A1 19890406 - GENENTECH INC [US]
- See references of WO 8901940A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8901940 A1 19890309; AU 2482988 A 19890331; AU 626007 B2 19920723; DK 216589 A 19890704; DK 216589 D0 19890503; EP 0347435 A1 19891227; EP 0347435 A4 19911121; ES 2013346 A6 19900501; GR 1000489 B 19920730; GR 880100579 A 19890622; IL 87647 A0 19890228; JP H02501192 A 19900426; KR 890701605 A 19891221; NO 891818 D0 19890502; NO 891818 L 19890703; NZ 226040 A 19920225; OA 09625 A 19930430; PT 88425 A 19890731; PT 88425 B 19921030
DOCDB simple family (application)
US 8802940 W 19880901; AU 2482988 A 19880901; DK 216589 A 19890503; EP 88908543 A 19880901; ES 8802727 A 19880905; GR 880100579 A 19880905; IL 8764788 A 19880901; JP 50773988 A 19880901; KR 890700813 A 19890508; NO 891818 A 19890502; NZ 22604088 A 19880905; OA 59745 A 19900301; PT 8842588 A 19880905