Global Patent Index - EP 0349869 A2

EP 0349869 A2 19900110 - Process for production of 1alfa, 3beta, 24-trihydroxy-delta5-steroids.

Title (en)

Process for production of 1alfa, 3beta, 24-trihydroxy-delta5-steroids.

Title (de)

Verfahren zur Herstellung von 1-alpha,3-beta,24-Trihydroxy-delta-5-Steroidderivaten.

Title (fr)

Procédé de préparation de 1-alpha, 3-bêta, 24-trihydroxy-delta 5-stéroides.

Publication

EP 0349869 A2 19900110 (EN)

Application

EP 89111561 A 19890624

Priority

JP 16514888 A 19880704

Abstract (en)

A process for production of a 1 alpha ,3 beta ,24-trihydroxy- DELTA <5>-steroid represented by the formula (II): <CHEM> wherein R1 and R2, independently, represent a hydrogen atom, or R1 and R2 together form a single bond, R3 represents an unsubstituted or halogen-substituted lower alkyl, and R4 represents a hydrogen atom, hydroxy or a protected hydroxy, comprising reducing a 1 alpha ,2 alpha -epoxy- DELTA <4,6>-3,24-dioxosteroid represented by the formula (I) <CHEM> wherein R1, R2, R3 and R4 have the same meanings an defined in formula (II), using an alkaline metal or alkaline earth metal and a proton donor in a solvent comprising ammonia or amine characterized in that at an early stage of the reaction the 1 alpha ,2 alpha -epoxy- DELTA <4,6>-3,24-dioxosteroid is reacted with the alkaline metal or alkaline earth metal in the presence of the proton acceptor, and then at a later stage of the reaction, a resulting intermediate product is reacted with the proton donor.

IPC 1-7

C07J 9/00; C07J 75/00

IPC 8 full level

C07J 9/00 (2006.01); C07J 13/00 (2006.01); C07J 75/00 (2006.01)

CPC (source: EP US)

C07J 9/00 (2013.01 - EP US); C07J 75/00 (2013.01 - EP US)

Designated contracting state (EPC)

AT BE CH DE ES FR GB IT LI NL SE

DOCDB simple family (publication)

EP 0349869 A2 19900110; EP 0349869 A3 19900425; EP 0349869 B1 19950830; AT E127126 T1 19950915; DE 68924010 D1 19951005; DE 68924010 T2 19960125; DK 174183 B1 20020819; DK 316689 A 19900105; DK 316689 D0 19890626; ES 2076175 T3 19951101; JP H0215093 A 19900118; JP H0749435 B2 19950531; PT 91011 A 19900208; PT 91011 B 19950131; US 5117015 A 19920526

DOCDB simple family (application)

EP 89111561 A 19890624; AT 89111561 T 19890624; DE 68924010 T 19890624; DK 316689 A 19890626; ES 89111561 T 19890624; JP 16514888 A 19880704; PT 9101189 A 19890629; US 69625591 A 19910430