EP 0357134 B1 19950628 - Antihypertensive 3-piperidinyl-indazole derivatives.
Title (en)
Antihypertensive 3-piperidinyl-indazole derivatives.
Title (de)
Antihypertensive 3-Piperidinylindazol-Derivate.
Title (fr)
Dérivés de 3-pipéridinyl-indazole antihypertensifs.
Publication
Application
Priority
US 23991588 A 19880902
Abstract (en)
[origin: EP0357134A1] Novel antihypertensive 3-piperidinyl-indazole derivatives of formula <CHEM> wherein R<1> is hydrogen or C1-6alkyl; R<2> is hydrogen; C1-6alkyl; substituted C1-6alkyl; optionally substituted phenyl; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl or phenylcarbonyl, wherein phenyl may be substituted; R<3> and R<4> are hydrogen, halo, hydroxy, C1-6alkyloxy or C1-6alkyl; Q is a bicyclic heterocyclic radical of formula <CHEM> the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are antihypertensive agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
IPC 1-7
C07D 471/04; C07D 513/04; C07D 498/04; C07D 401/14; A61K 31/495; A61K 31/425; A61K 31/42; A61K 31/505
IPC 8 full level
A61K 31/4184 (2006.01); A61K 31/44 (2006.01); A61K 31/4427 (2006.01); A61K 31/445 (2006.01); A61K 31/505 (2006.01); A61P 1/12 (2006.01); A61P 3/04 (2006.01); A61P 9/12 (2006.01); A61P 25/00 (2006.01); A61P 25/06 (2006.01); A61P 25/18 (2006.01); A61P 25/24 (2006.01); A61P 25/30 (2006.01); A61P 25/32 (2006.01); A61P 25/34 (2006.01); A61P 43/00 (2006.01); C07D 401/14 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01); C07D 521/00 (2006.01)
CPC (source: EP KR)
A61P 1/12 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/06 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/30 (2017.12 - EP); A61P 25/32 (2017.12 - EP); A61P 25/34 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/14 (2013.01 - EP KR); C07D 403/14 (2013.01 - KR); C07D 471/04 (2013.01 - EP); C07D 513/04 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
EP 0357134 A1 19900307; EP 0357134 B1 19950628; AT E124410 T1 19950715; AU 4084889 A 19900308; AU 614871 B2 19910912; CA 1331610 C 19940823; CN 1024346 C 19940427; CN 1040589 A 19900321; DE 68923231 D1 19950803; DE 68923231 T2 19951109; DK 169547 B1 19941128; DK 434789 A 19900303; DK 434789 D0 19890901; ES 2076201 T3 19951101; FI 894125 A0 19890901; FI 894125 A 19900303; FI 91864 B 19940513; FI 91864 C 19940825; GR 3017435 T3 19951231; HU 202232 B 19910228; HU T51622 A 19900528; IE 66511 B1 19960110; IE 892829 L 19900302; IL 90879 A0 19900209; JP 2768992 B2 19980625; JP H02160778 A 19900620; KR 0145705 B1 19980817; KR 900004721 A 19900412; NO 176608 B 19950123; NO 176608 C 19950503; NO 893523 D0 19890901; NO 893523 L 19900305; NZ 230367 A 19910326; PH 26456 A 19920727; PT 91613 A 19900330; PT 91613 B 19950504; SU 1720489 A3 19920315; ZA 896741 B 19910529
DOCDB simple family (application)
EP 89202152 A 19890825; AT 89202152 T 19890825; AU 4084889 A 19890828; CA 606920 A 19890728; CN 89106733 A 19890902; DE 68923231 T 19890825; DK 434789 A 19890901; ES 89202152 T 19890825; FI 894125 A 19890901; GR 950402560 T 19950918; HU 454189 A 19890901; IE 282989 A 19890901; IL 9087989 A 19890705; JP 22476289 A 19890901; KR 890012700 A 19890902; NO 893523 A 19890901; NZ 23036789 A 19890818; PH 39128 A 19890822; PT 9161389 A 19890901; SU 4742322 A 19890829; ZA 896741 A 19890901