EP 0370458 B1 19970115 - Synthetic DNA derived recombinant HIV-1 antigens
Title (en)
Synthetic DNA derived recombinant HIV-1 antigens
Title (de)
Von synthetischer DNS abgeleitete rekombinante HIV-1-Antigene
Title (fr)
Antigènes à partir d'ADN synthétique dérivé du virus de l'immunodéficience humaine (HIV-1) recombinant
Publication
Application
Priority
US 27530988 A 19881123
Abstract (en)
[origin: EP0370458A2] The present invention provides a method of synthesizing genes encoding unique HIV-1 and HIV-2 envelope proteins and their fragments, thereby allowing overexpression of these proteins in E. coli. The HIV envelope proteins and their fragments have been expressed at high levels as individual proteins or in fusion with other proteins. The HIV envelope proteins thus expressed in E. coli can be effectively used for the detection of exposure to HIV as well as the discrimination of HIV-1 and HIV-2.
IPC 1-7
IPC 8 full level
G01N 33/569 (2006.01); A61K 39/21 (2006.01); C07K 1/00 (2006.01); C07K 14/00 (2006.01); C07K 14/155 (2006.01); C07K 14/16 (2006.01); C07K 14/195 (2006.01); C07K 14/41 (2006.01); C07K 14/705 (2006.01); C07K 19/00 (2006.01); C12N 9/00 (2006.01); C12N 15/09 (2006.01); C12N 15/48 (2006.01); C12P 21/02 (2006.01); C12R 1/19 (2006.01)
CPC (source: EP US)
C07K 14/005 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); C07K 2319/31 (2013.01 - EP US); C07K 2319/40 (2013.01 - EP US); C12N 2740/16122 (2013.01 - EP US)
Citation (examination)
GENE, vol. 45, no. 3, 1986, pages 317-325, Elsevier Science B.V. (Biomedical Division), Amsterdam (NL); K.A. KELLEY et al., pp. 317-325
Designated contracting state (EPC)
AT BE CH DE ES FR GB GR IT LI NL SE
DOCDB simple family (publication)
EP 0370458 A2 19900530; EP 0370458 A3 19911106; EP 0370458 B1 19970115; AT E147758 T1 19970215; AT E286978 T1 20050115; AU 4545889 A 19900705; AU 628108 B2 19920910; CA 2003383 A1 19900523; DE 68927665 D1 19970227; DE 68927665 T2 19970717; DE 68929529 D1 20050217; DE 68929529 T2 20051229; EP 0717109 A1 19960619; EP 0717109 B1 20050112; ES 2099066 T3 19970516; ES 2238071 T3 20050816; GR 3022850 T3 19970630; JP 3073752 B2 20000807; JP H02273187 A 19901107; JP H11313671 A 19991116; US 5859193 A 19990112; US 6153377 A 20001128; US 6538127 B1 20030325
DOCDB simple family (application)
EP 89121513 A 19891121; AT 89121513 T 19891121; AT 95114545 T 19891121; AU 4545889 A 19891122; CA 2003383 A 19891120; DE 68927665 T 19891121; DE 68929529 T 19891121; EP 95114545 A 19891121; ES 89121513 T 19891121; ES 95114545 T 19891121; GR 970400525 T 19970317; JP 30635389 A 19891124; JP 4811199 A 19990225; US 31457094 A 19940929; US 44353095 A 19950518; US 44396195 A 19950518