EP 0371056 A4 19901219 - METHODS AND COMPOSITIONS FOR MIMICKING ANTIGENIC DETERMINANTS
Title (en)
METHODS AND COMPOSITIONS FOR MIMICKING ANTIGENIC DETERMINANTS
Publication
Application
Priority
US 8354187 A 19870807
Abstract (en)
[origin: WO8901337A1] Novel methods useful in the analysis of antigen/antibody reactions and the study of antigenic determinants and immunoglobulins are provided. A novel method is provided wherein an immortal cell line capable of expressing an immunoglobulin molecule, which molecule is the anti-idiotype of an antigen binding substance of interest, is substituted for the antigenic determinant or epitope bound by the antigen binding substance. The cells of the cell line are manipulated to provide the immunoglobulin as a cell surface marker. This results in a stable, efficient source of an antigenic determinant of interest, makes accessible previously unaccessible epitopes and amplifies markers previously found on substances not amenable to FACS analysis.
IPC 1-7
A61K 39/00; C12P 21/00; G01N 21/76; G01N 33/53; G01N 33/554; G01N 33/566
IPC 8 full level
G01N 33/53 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); C07K 16/42 (2006.01); C12N 5/10 (2006.01); C12N 15/02 (2006.01); C12P 21/08 (2006.01); G01N 33/50 (2006.01); G01N 33/531 (2006.01); G01N 33/577 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61K 47/6873 (2017.07); C07K 16/4266 (2013.01); G01N 33/5005 (2013.01)
Citation (search report)
- No further relevant documents have been disclosed.
- See references of WO 8901337A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8901337 A1 19890223; EP 0371056 A1 19900606; EP 0371056 A4 19901219; JP H03501161 A 19910314; NZ 225371 A 19900626; ZA 885125 B 19890426
DOCDB simple family (application)
US 8802342 W 19880712; EP 88906638 A 19880712; JP 50643588 A 19880712; NZ 22537188 A 19880712; ZA 885125 A 19880715