Global Patent Index - EP 0372670 A3

EP 0372670 A3 19910821 - HIRUDIN PEPTIDES FOR INHIBITING PLATELET AGGREGATION

Title (en)

HIRUDIN PEPTIDES FOR INHIBITING PLATELET AGGREGATION

Publication

EP 0372670 A3 19910821 (EN)

Application

EP 89302159 A 19890303

Priority

US 28061888 A 19881205

Abstract (en)

[origin: EP0372670A2] This invention relates to anticoagulant and platelet inhibitory compositions, combinations and methods characterized by biologically active peptides which display the anticoagulant and platelet inhibitory activities of hirudin, or analogs thereof, for therapeutic and prophylactic purposes. The methods, compositions and combinations of this invention are advantageously useful for decreasing or preventing platelet aggregation and platelet activation in a patient or a biological sample. These methods, compositions and combinations are particularly useful in patients for whom standard heparin therapy is contraindicated due to a history of heparin-induced thrombocytopenia or an antithrombin III deficiency. This invention also relates to methods, compositions and combinations for treating extracorporeal blood and for increasing platelet storage life.

IPC 1-7

A61K 37/02

IPC 8 full level

A61K 38/00 (2006.01); A61K 31/415 (2006.01); A61K 31/435 (2006.01); A61K 31/505 (2006.01); A61K 31/52 (2006.01); A61K 31/555 (2006.01); A61K 31/557 (2006.01); A61K 31/60 (2006.01); A61K 31/70 (2006.01); A61K 38/55 (2006.01); A61K 39/395 (2006.01); A61P 7/02 (2006.01); C07K 14/815 (2006.01)

CPC (source: EP)

A61P 7/02 (2017.12); C07K 14/815 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

  • [X] EP 0276014 A2 19880727 - MERRELL DOW PHARMA [US]
  • [E] EP 0333356 A2 19890920 - BIOGEN INC [US]
  • [X] JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 9, 1987, pages 1688-1691, American Chemical Society; J.L. KRSTENANSKY et al.: "Anticoagulant peptides: Nature of the interaction of the C-terminal region of hirudin with a noncatalytic binding site on thrombin"
  • [X] BIOCHEMISTRY, vol. 27, no. 21, 1988, pages 8170-8173, American Chemical Society; S.J.T. MAO et al.: "Interaction of hirudin with thrombin: Identification of a minimal binding domain of hirudin that inhibits clotting activity"
  • [X] BLOOD, THE JOURNAL OF THE AMERICAN SOCIETY OF HEMATOLOGY, vol. 72, no. 5, suppl. 1, November 1988, page 326a, abstract no. 1213; J.A. JAKUBOWSKI et al.: "Inhibition of thrombin-induced platelet activities by a synthetic 12 amino acid residue sulfated peptide (Hirügen)"

Designated contracting state (EPC)

AT BE CH DE ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0372670 A2 19900613; EP 0372670 A3 19910821; AU 3098189 A 19900607; AU 623882 B2 19920528; DK 210690 A 19910603; DK 210690 D0 19900903; FI 904329 A0 19900903; HU T57060 A 19911128; JP H04503660 A 19920702; WO 9006128 A1 19900614

DOCDB simple family (application)

EP 89302159 A 19890303; AU 3098189 A 19890303; DK 210690 A 19900903; FI 904329 A 19900903; HU 286089 A 19890302; JP 50497789 A 19890302; US 8900849 W 19890302