EP 0379708 B1 19941207 - Fungi strain Tolypocladiam varium and process for obtaining complexes of antibiotic cyclosporin and/or its components.
Title (en)
Fungi strain Tolypocladiam varium and process for obtaining complexes of antibiotic cyclosporin and/or its components.
Title (de)
Pilzart Tolypocladium varium und Verfahren zur Herstellung des Antibioticumkomplexes Cyclosporin und/oder seiner Bestandteile.
Title (fr)
Souche de champignon tolypocladiam varium et procédé pour obtenir des complexes de l'antibiotique cyclosporine et/ou ses composants.
Publication
Application
Priority
HU 649788 A 19881220
Abstract (en)
[origin: GB2227489A] A microbial process for the production of immunosuppressive cyclosporin anti-biotic complex or of its components, cyclosporin A, cyclosporin B and cyclosporin C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed is described, which comprises culturing a strain of Tolypocladium varium fungus species producing the cyclosporin antibiotic complex, preferably Tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25 to 30 DEG C, and, if desired, isolating and purifying the cyclosporin antibiotic complex or its components produced.
IPC 1-7
IPC 8 full level
A61K 31/545 (2006.01); A61K 38/00 (2006.01); A61P 37/06 (2006.01); C07D 501/00 (2006.01); C07K 7/64 (2006.01); C12P 1/00 (2006.01); C12N 1/14 (2006.01); C12P 21/04 (2006.01); C12P 35/00 (2006.01); C12R 1/645 (2006.01)
CPC (source: EP US)
A61P 37/06 (2018.01 - EP); C07K 7/645 (2013.01 - EP US); C12N 1/145 (2021.05 - EP US); C12R 2001/645 (2021.05 - EP US); Y10S 435/911 (2013.01 - EP US)
Designated contracting state (EPC)
DE
DOCDB simple family (publication)
EP 0379708 A1 19900801; EP 0379708 B1 19941207; AT 393135 B 19910826; AT A289189 A 19910115; BG 60274 B1 19940331; BG 60274 B2 19940331; CA 2006144 A1 19900620; CA 2006144 C 19950221; CZ 283557 B6 19980513; CZ 722589 A3 19980114; DD 290356 A5 19910529; DE 58908740 D1 19950119; DK 174719 B1 20031006; DK 640989 A 19900621; DK 640989 D0 19891218; FI 896157 A0 19891220; FI 92603 B 19940831; FI 92603 C 19941212; FR 2640641 A1 19900622; FR 2640641 B1 19910510; GB 2227489 A 19900801; GB 2227489 B 19920916; GB 8928715 D0 19900228; HU 201577 B 19901128; HU T52164 A 19900628; IT 1237799 B 19930831; IT 8922765 A0 19891220; JP H02231071 A 19900913; JP H0763356 B2 19950712; LV 10102 A 19940510; LV 10102 B 19950220; LV 10500 A 19950220; LV 10500 B 19950820; NO 175873 B 19940912; NO 175873 C 19941221; NO 895160 D0 19891220; NO 895160 L 19900621; PL 162959 B1 19940131; RU 1836425 C 19930823; SE 505442 C2 19970825; SE 8904262 D0 19891219; SE 8904262 L 19900621; SK 279768 B6 19990312; SK 722589 A3 19990310; UA 13320 A 19970228; US 5156960 A 19921020; YU 241589 A 19910228; YU 47100 B 19941228
DOCDB simple family (application)
EP 89123535 A 19891220; AT 289189 A 19891220; BG 9070189 A 19891220; CA 2006144 A 19891220; CS 722589 A 19891220; DD 33597789 A 19891220; DE 58908740 T 19891220; DK 640989 A 19891218; FI 896157 A 19891220; FR 8916878 A 19891220; GB 8928715 A 19891220; HU 649788 A 19881220; IT 2276589 A 19891220; JP 32852989 A 19891220; LV 920010 A 19920504; LV 930708 A 19930628; NO 895160 A 19891220; PL 28287689 A 19891220; SE 8904262 A 19891219; SK 722589 A 19891220; SU 4742791 A 19891219; UA 4742791 A 19891219; US 45400589 A 19891220; YU 241589 A 19891220