Global Patent Index - EP 0383635 A3

EP 0383635 A3 19911227 - PEPTIDES HAVING RENIN INHIBITORY ACTIVITY THEIR PREPARATION AND USE

Title (en)

PEPTIDES HAVING RENIN INHIBITORY ACTIVITY THEIR PREPARATION AND USE

Publication

EP 0383635 A3 19911227 (EN)

Application

EP 90301735 A 19900216

Priority

  • JP 3709789 A 19890216
  • JP 14957789 A 19890614

Abstract (en)

[origin: EP0383635A2] Compounds of formula (I): <CHEM> [in which: R<1> is heterocyclic group having 5 or 6 ring atoms, or -NR<7>R<8>, where R<7> is alkyl and R<8> is optionally substituted phenyl, optionally substituted phenylalkyl or cycloalkyl; R<2> is optionally substituted phenyl or naphthyl; R<3> is thiazolyl; R<4> is cyclohexyl or isopropyl; R<5> is alkyl; and R<6> is alkyl] and salts thereof have renin-inhibitory and, hence, hypotensive activities and are of value in the diagnosis and treatment of hypertension induced by failures in the renin-angiotensin system. They may be prepared by reacting together appropriate amino acids or derivatives thereof.

IPC 1-7

C07K 5/02; C07D 277/30; A61K 37/64

IPC 8 full level

A61K 31/425 (2006.01); C07D 277/30 (2006.01); C07D 413/06 (2006.01)

CPC (source: EP KR US)

C07D 277/30 (2013.01 - EP US); C07K 5/10 (2013.01 - KR)

Citation (search report)

  • [A] EP 0228192 A2 19870708 - SANKYO CO [JP]
  • [A] EP 0192554 A1 19860827 - SANOFI SA [FR], et al
  • [Y] CHEMICAL ABSTRACTS, vol. 110, 1989, page 829, abstract no. 173756u, Columbus, Ohio, US; & JP-A-61 302 983 (SANKYO CO., LTD) 13-07-1988
  • [Y] JOURNAL OF MEDICAL CHEMISTRY, vol. 31, 1988, pages 1839-1846, American Chemical Society; P. BÜHLMAYER et al.: "Synthesis and biological activity of some transition-state inhibitors of human renin"

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0383635 A2 19900822; EP 0383635 A3 19911227; EP 0383635 B1 19950712; AT E124867 T1 19950715; CA 2010260 A1 19900816; DE 69020752 D1 19950817; DE 69020752 T2 19960328; DK 0383635 T3 19951120; ES 2077021 T3 19951116; GR 3017697 T3 19960131; IE 70080 B1 19961030; IE 900585 L 19900816; KR 900012945 A 19900903; US 5378689 A 19950103

DOCDB simple family (application)

EP 90301735 A 19900216; AT 90301735 T 19900216; CA 2010260 A 19900216; DE 69020752 T 19900216; DK 90301735 T 19900216; ES 90301735 T 19900216; GR 950402806 T 19951011; IE 58590 A 19900216; KR 900001918 A 19900216; US 9874693 A 19930728