EP 0383799 A1 19900829 - ADHESON VARIANTS.
Title (en)
ADHESON VARIANTS.
Title (de)
ADHÄSIONSVARIANTEN.
Title (fr)
VARIANTES D'ADHESON.
Publication
Application
Priority
- US 10432987 A 19871002
- US 8803414 W 19881003
- US 25078588 A 19880928
Abstract (en)
[origin: WO8902922A1] Novel derivatives of cell surface proteins which are homologous to the immunoglobulin superfamily (adhesons) are provided. Amio acid sequence variations are introduced into adheson, the most noteworthy of which are those in which the transmembrane and, preferably, cytoplasmic domains are rendered functionally inactive, and in which adheson extracellular domains replace an immunoglobulin variable region. These variants are useful in therapy or diagnostics, in particular, CD4 variants are therapeutically useful in the treatment of HIV infections.
Abstract (fr)
De nouveaux dérivés de protéines cellulaires de surface sont homologues à la superfamille de l'immunoglobuline (adhésons). On introduit dans des adhésons des variations de leur séquence d'acides aminés, dont les plus notables sont celles qui rendent fonctionnellement inactifs des domaines transmembraniques et, de préférence, cytoplasmiques, et où des domaines extracellulaires de l'adhéson remplacent une région variable de l'immunoglobuline. Ces variantes sont utiles pour la thérapie et le diagnostic, les variantes CD4 notamment étant utiles pour le traitement d'infections par VIH.
IPC 1-7
IPC 8 full level
C12P 21/08 (2006.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61P 31/12 (2006.01); A61P 37/04 (2006.01); C07K 1/22 (2006.01); C07K 14/34 (2006.01); C07K 14/435 (2006.01); C07K 14/705 (2006.01); C07K 14/73 (2006.01); C07K 14/76 (2006.01); C07K 16/00 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); G01N 33/68 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61K 47/6425 (2017.07); A61P 31/12 (2017.12); A61P 37/04 (2017.12); C07K 14/34 (2013.01); C07K 14/70514 (2013.01); C07K 16/00 (2013.01); G01N 33/6854 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/32 (2013.01); C07K 2319/55 (2013.01)
Citation (search report)
See references of WO 8902922A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8902922 A1 19890406; AT E166387 T1 19980615; CA 1341427 C 20030422; DE 3856189 D1 19980625; DE 3856189 T2 19981105; DE 3856189 T3 20051110; DK 175930 B1 20050711; DK 80590 A 19900530; DK 80590 D0 19900330; EP 0314317 A1 19890503; EP 0314317 B1 19980826; EP 0314317 B2 20050323; EP 0383799 A1 19900829; EP 0383799 B1 19980520; EP 0383799 B2 20050209; ES 2121733 T3 19981216; ES 2121733 T5 20051016; HK 1010790 A1 19990625; JP 2888529 B2 19990510; JP H04502850 A 19920528; NO 303580 B1 19980803; NO 901311 D0 19900321; NO 901311 L 19900321; NZ 226414 A 19920728; PT 88641 A 19881001; PT 88641 B 19930430
DOCDB simple family (application)
US 8803414 W 19881003; AT 88909155 T 19881003; CA 579192 A 19881003; DE 3856189 T 19881003; DK 80590 A 19900330; EP 88309194 A 19881003; EP 88909155 A 19881003; ES 88309194 T 19881003; HK 98111679 A 19981030; JP 50852088 A 19881003; NO 901311 A 19900321; NZ 22641488 A 19880930; PT 8864188 A 19880930