Global Patent Index - EP 0384130 A3

EP 0384130 A3 19910529 - MYOCARDIAL INFARCTION IMMUNOASSAY

Title (en)

MYOCARDIAL INFARCTION IMMUNOASSAY

Publication

EP 0384130 A3 19910529 (EN)

Application

EP 90101237 A 19900122

Priority

  • US 29927789 A 19890123
  • US 7603887 A 19870721

Abstract (en)

[origin: EP0304628A2] Methods and reagents for early detection of myocardial infarction determine the level of CK-MMA and the level of the combined CK-MMA and CK-MMB in in a serum sample. From these measurements, the time of the acute phase can be more accurately determined. Novel anti-(CK-MMA) antibodies, anti-(CK-MMB) antibodies, anti-(CK-MM(A+B)) antibodies, labeled and insolubilized derivatives of these antibodies, labeled MMA, and kits containing one or more of these reagents are also described.

IPC 1-7

G01N 33/573; C12P 21/08; C12N 5/18

IPC 8 full level

C12Q 1/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 16/40 (2006.01); C12N 9/04 (2006.01); C12Q 1/50 (2006.01); G01N 33/573 (2006.01)

CPC (source: EP US)

C07K 14/47 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); C07K 16/40 (2013.01 - EP US); C12N 9/0006 (2013.01 - EP US); G01N 33/573 (2013.01 - EP US); Y10S 436/811 (2013.01 - EP US); Y10S 436/815 (2013.01 - EP US)

Citation (search report)

  • [XP] EP 0304628 A2 19890301 - INT IMMUNOASSAY LAB INC [US]
  • [XP] EP 0339814 A1 19891102 - UNITIKA LTD [JP], et al
  • [YD] CLINICAL CHEMISTRY, vol. 30, no. 5, 1984, pages 662-664; M.B. PERRYMAN et al.: "Carboxypeptidase-catalyzed hydrolysis of C-terminal lysine: Mechanism for in vivo production of multiple forms of creatine kinase in plasma"
  • [YD] CIRCULATION, vol. 74, no. 1, July 1986, pages 105-109; A.S. JAFFE et al.: "Diagnostic changes in plasma creatine kinase isoforms early after the onset of acute myocardial infarction"
  • [AD] BIOCHIMICA ET BIOPHYSICA ACTA, vol. 790, 1984, pages 230-237; H. VAIDYA et al.: "Purification of five creatine kinase-MM variants from human heart and skeletal muscle"
  • [A] BIOLOGICAL ABSTRACTS, vol. 87, no. 12, 1989, abstract no. 123149, Biological Abstracts, Inc., Philadelphia, PA, US; K. VAGENKNEKHT et al.: "Malate dehydrogenase isoenzymes, in myocardial infarction", & KARDIOLOGIYA 28(11): 55-57. 1988
  • [A] CLINICAL CHEMISTRY, vol. 33, no. 11, 1987, pages 2039-2042; M. PANTEGHINI et al.: "Isoforms of creatine kinase isoenzymes in serum in acute myocardial infarction after intracoronary thrombolysis"

Designated contracting state (EPC)

AT BE CH DE ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0304628 A2 19890301; EP 0304628 A3 19910717; CA 1303496 C 19920616; CA 2008360 A1 19900723; EP 0384130 A2 19900829; EP 0384130 A3 19910529; JP S6454260 A 19890301; US 4900662 A 19900213; US 5202234 A 19930413

DOCDB simple family (application)

EP 88111778 A 19880721; CA 2008360 A 19900123; CA 572570 A 19880720; EP 90101237 A 19900122; JP 18043988 A 19880721; US 29927789 A 19890123; US 7603887 A 19870721