EP 0386143 A1 19900912 - TRI- AND TETRA-SUBSTITUTED-OXETANES AND TETRAHYDROFURANS AND INTERMEDIATES THEREOF.
Title (en)
TRI- AND TETRA-SUBSTITUTED-OXETANES AND TETRAHYDROFURANS AND INTERMEDIATES THEREOF.
Title (de)
TRI- UND TETRA-SUBSTITUIERTE OXETANE UND TETRAHYDROFURANE UND DEREN ZWISCHENPRODUKTE.
Title (fr)
OXETANES ET TETRAHYDROFURANES TRI ET TETRASUBSTITUEES ET LEURS PRODUITS INTERMEDIAIRES.
Publication
Application
Priority
US 12350087 A 19871120
Abstract (en)
[origin: WO8904829A1] This invention relates to tri- and tetra-substituted-oxetanes, of formula (I), e.g. (+/-)-cis- and (+/-)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4-di halophenyl)-4-[(1H- 1H-1,2,4-triazol-1-yl)methyl]oxetane and tri- and tetra-substituted-tetrahydrofurans, e.g. (+/-)-cis- and (+/-)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro-2-[(1H-azol-1-yl)met hyl]-5-furanyl]methoxy]phenyl]-4-yl-1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.
Abstract (fr)
Oxétanes tri et tétrasubstitués ayant la formule (I), par exemple (U)-cis- et (U)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxyl)méthyle]-4-(2,4-dihalo-phényle)-4-[(1H- 1H-1,2,4-triazol-1-yle)méthyl]oxétane, tétrahydrofuranes tri et tétrasubstituées, par exemple pipérazine-3-one (U)-cis- et (U)-trans-1-[4-[[2-(2,4-dihalophényl)tétrahydro-2-[(1H-azol-1-yl)méthyl]-5-furanyl]méthoxyl]phényl]-4-yl-1-substituée et dérivés associés qui présentent une activité fongicide et antiallergique, leurs compositions pharmaceutiques, leurs procédés d'utilisation pour le traitement ou la prévention d'infections par susceptibilité à des champignons et de réactions allergiques dans un hôte, y compris des animaux à sang chaud tels que des êtres humains.
IPC 1-7
A61K 31/38; A61K 31/415; A61K 31/44; C07D 405/06; C07D 405/14; C07D 409/14; C07D 473/10
IPC 8 full level
C07D 473/08 (2006.01); A61K 31/41 (2006.01); A61K 31/415 (2006.01); A61K 31/425 (2006.01); A61K 31/44 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/495 (2006.01); A61K 31/52 (2006.01); A61K 31/522 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 37/08 (2006.01); C07D 405/06 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 473/10 (2006.01); C07D 493/08 (2006.01); C07D 521/00 (2006.01)
CPC (source: EP)
A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 37/08 (2017.12); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 249/08 (2013.01); C07D 473/10 (2013.01)
Citation (search report)
See references of WO 8904829A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8904829 A1 19890601; AT E115577 T1 19941215; AU 2811689 A 19890614; DE 3852477 D1 19950126; DE 3852477 T2 19950504; EP 0318214 A1 19890531; EP 0318214 B1 19941214; EP 0386143 A1 19900912; ES 2065340 T3 19950216; GR 3015217 T3 19950531; HK 186296 A 19961011; JP H02504033 A 19901122; JP H0717634 B2 19950301; JP H07196506 A 19950801
DOCDB simple family (application)
US 8803987 W 19881118; AT 88310904 T 19881118; AU 2811689 A 19891118; DE 3852477 T 19881118; EP 88310904 A 19881118; EP 89900481 A 19881118; ES 88310904 T 19881118; GR 950400421 T 19950228; HK 186296 A 19961003; JP 21779294 A 19940809; JP 50027189 A 19881118