EP 0393145 A4 19910911 - SPONTANEOUS VESICULATION OF MULTILAMELLAR LIPOSOMES
Title (en)
SPONTANEOUS VESICULATION OF MULTILAMELLAR LIPOSOMES
Publication
Application
Priority
- US 13626787 A 19871222
- US 23670088 A 19880825
Abstract (en)
[origin: WO8905636A1] A new method is disclosed for making unilamellar vesicles from multilamellar vesicles. Such vesicles are formed without the use of physical or chemical disruption processes known in the art for forming unilamellar vesicles. The liposomes are incubated at neutral pH at or near the transition temperature of the lipids used, in low ionic strength media such as distilled water. The liposomes may comprise bioactive agents, such as the toxic hydrophobic drugs such as the polyene antibiotic amphotericin B, and may be used in vivo or in vitro. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio.
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01); A61K 9/133 (2006.01); B01J 13/02 (2006.01)
CPC (source: EP)
A61K 9/1277 (2013.01)
Citation (search report)
- [Y] US 4663167 A 19870505 - LOPEZ-BERESTEIN GABRIEL [US], et al
- See references of WO 8905636A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8905636 A1 19890629; CA 1330199 C 19940614; EP 0393145 A1 19901024; EP 0393145 A4 19910911; JP H03501732 A 19910418
DOCDB simple family (application)
US 8804632 W 19881222; CA 586752 A 19881222; EP 89901663 A 19881222; JP 50160989 A 19881222