Global Patent Index - EP 0395418 A1

EP 0395418 A1 19901031 - A phospholipase A2 inhibitor, method for producing it and pharmaceutical or veterinary formulations comprising said inhibitor.

Title (en)

A phospholipase A2 inhibitor, method for producing it and pharmaceutical or veterinary formulations comprising said inhibitor.

Title (de)

Phospholipase-A2-Inhibitor, Verfahren zu seiner Herstellung und diesen enthaltende pharmazeutische oder veterinäre Zusammensetzungen.

Title (fr)

Inhibiteur de A2-phospholipase, procédé pour sa préparation et compositions pharmaceutiques ou vétérinaires le contenant.

Publication

EP 0395418 A1 19901031 (EN)

Application

EP 90304552 A 19900426

Priority

JP 10993989 A 19890428

Abstract (en)

A compound of the formula: <CHEM> wherein the wave line means alpha -bond or beta -bond, which compound is useful as a phospholipase A2 inhibitor. Process for the production of the compound, pharmaceutical composition containing the compound, and a cell culture of a microorganism Thielavia terricola RF-143 producing the compound are also provided.

IPC 1-7

A61K 31/35; C07D 311/82; C12N 1/14; C12P 17/06

IPC 8 full level

C12P 1/02 (2006.01); A61K 38/55 (2006.01); A61P 3/00 (2006.01); A61P 7/00 (2006.01); A61P 9/02 (2006.01); A61P 25/08 (2006.01); C07D 311/82 (2006.01); C07K 14/005 (2006.01); C07K 14/195 (2006.01); C07K 14/37 (2006.01); C07K 14/41 (2006.01); C12N 9/99 (2006.01); C12P 17/06 (2006.01); C12R 1/645 (2006.01)

CPC (source: EP US)

A61P 3/00 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 9/02 (2017.12 - EP); A61P 25/08 (2017.12 - EP); C07D 311/82 (2013.01 - EP US); C12N 1/145 (2021.05 - EP US); C12P 17/06 (2013.01 - EP US); C12R 2001/645 (2021.05 - EP US)

Citation (search report)

  • [A] CHEMICAL ABSTRACTS, vol. 108, no. 17, 25 April 1988 Columbus, Ohio, USA Suarna,Cacang et al.: "Oxidations of vitamin E (a-tocopherol) and its model compound.2,2,5,7,8Pentamethyl-6-hydroxychroman.A new dimer." page 775; column 2; ref. no. 150753K
  • [A] CHEMICAL ABSTRACTS, vol. 110, no. 13, 27 March 1989 Columbus, Ohio, USA Kolly,Sandra et al.: "4,10a-(Epidithio)-4,4a,10, 10a-tetrahydro-1H-5-oxaanthracen-1-ones,tetracycles with a novel heterocyclic ring system" page 672; column 2; ref. no. 114635F
  • [A] CHEMICAL ABSTRACTS, vol. 91, no. 25, 17 December 1979 Columbus, Ohio, USA Endo,Akira et al.: "Thielavin A and B." page 519,; column 2; ref. no. 209363U
  • [A] CHEMICAL ABSTRACTS, vol. 96, no. 7, 15 February 1982 Columbus, Ohio, USA Kitahara,Nobuaki et al.: "Thielavin A and B,new inhibitors of prostaglandin biosynthesis produced by Thielavia Terricola." page 295; column 1; ref. no. 48698T
  • [A] CHEMICAL ABSTRACTS, vol. 99, no. 5, 01 August 1983 Columbus, Ohio, USA Kitahara,Nobuaki et al.: "The structures of thielavins A,B and C. Prostaglandin synthetase inhibitors from fungi." page 506; column 2; ref. no. 38273Y
  • [AD] Bulletin of the Torrey Botanical Club vol. 57, no. 2, February 1930, Menasha,Winsconsin pages 123 - 126; Chester W. Emmons: "Coniothyrium terricola proves to be a species of Thielavia"
  • [AD] Supplément Colonial à la Revue de Mycologie vol. XXI, no. 1, 01 July 1956, Paris pages 1 - 21; Gaston Doguet: "Le genre Thielavia Zopf"

Designated contracting state (EPC)

AT BE CH DE DK ES FR GB GR IT LI LU NL SE

DOCDB simple family (publication)

EP 0395418 A1 19901031; EP 0395418 B1 19950524; AT E123028 T1 19950615; DE 69019591 D1 19950629; DE 69019591 T2 19960125; DK 0395418 T3 19950807; ES 2075154 T3 19951001; JP 2842613 B2 19990106; JP H02286088 A 19901126; US 5011952 A 19910430

DOCDB simple family (application)

EP 90304552 A 19900426; AT 90304552 T 19900426; DE 69019591 T 19900426; DK 90304552 T 19900426; ES 90304552 T 19900426; JP 10993989 A 19890428; US 51698290 A 19900430