EP 0396653 A1 19901114 - RECOMBINANT FUSION PROTEINS FOR ALTERING HORMONE SECRETION.
Title (en)
RECOMBINANT FUSION PROTEINS FOR ALTERING HORMONE SECRETION.
Title (de)
REKOMBINANTE SCHMELZ-PROTEINE ZUR MODIFIZIERUNG DER HORMONABSCHEIDUNG.
Title (fr)
PROTEINES DE FUSION RECOMBINANTES MODIFIANT LA SECRETION HORMONALE.
Publication
Application
Priority
US 24655888 A 19880830
Abstract (en)
[origin: WO9002187A1] A recombinant fusion protein, resulting from the expression of two genes regulated by a single promoter, having the effect of altering hormone secretion when administered in a therapeutically effective dose. One gene codes for the production of a highly antigenic, hydrophilic protein, such as hepatitis B surface antigen, and the other gene codes for a peptide which alone is not substantially antigenic, such as luteinizing hormone releasing hormone.
Abstract (fr)
L'invention concerne une protéine de fusion recombinante résultant de l'expression de deux gènes régulée par un seul promoteur, ayant pour effet de modifier la sécrétion hormonale lorsqu'on l'administre dans une dose thérapeutiquement efficace. Un gène code pour la production d'une protéine hydrophile hautement antigénique telle que l'antigène de surface de l'hépatite B, et l'autre gène code pour un peptide qui seul n'est pas sensiblement antigénique, tel que l'hormone de libération de la lutéostimuline.
IPC 1-7
IPC 8 full level
A61K 39/29 (2006.01); A61K 39/395 (2006.01); A61K 39/42 (2006.01); A61P 5/00 (2006.01); C07K 7/23 (2006.01); C07K 14/00 (2006.01); C07K 14/02 (2006.01); C07K 14/10 (2006.01); C07K 14/18 (2006.01); C07K 14/575 (2006.01); C07K 14/59 (2006.01); C07K 14/705 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); C12N 15/62 (2006.01); C12P 21/00 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 5/00 (2017.12); C07K 14/005 (2013.01); C07K 14/59 (2013.01); C12N 15/62 (2013.01); C07K 2319/40 (2013.01); C07K 2319/75 (2013.01); C12N 2730/10122 (2013.01)
Citation (search report)
See references of WO 9002187A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9002187 A1 19900308; AU 4076189 A 19900323; AU 629237 B2 19921001; DK 106590 A 19900430; DK 106590 D0 19900430; EP 0396653 A1 19901114; FI 902151 A0 19900427; GR 1000321 B 19920625; GR 890100540 A 19900822; IL 91462 A0 19900429; JP H03502584 A 19910613; ZA 896628 B 19910424
DOCDB simple family (application)
EP 8901013 W 19890829; AU 4076189 A 19890829; DK 106590 A 19900430; EP 89909550 A 19890829; FI 902151 A 19900427; GR 890100540 A 19890830; IL 9146289 A 19890829; JP 50896989 A 19890829; ZA 896628 A 19890830