EP 0410241 B1 19931020 - Aryl alkenoic acid derivatives as leukotriene antagonists.
Title (en)
Aryl alkenoic acid derivatives as leukotriene antagonists.
Title (de)
Arylalkensäurederivate als Leukotrienantagonisten.
Title (fr)
Dérivés d'acides arylalcénoiques à titre d'antagonistes du leucotriène.
Publication
Application
Priority
US 38654089 A 19890727
Abstract (en)
[origin: EP0410241A1] Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I <CHEM> in which X is -S-, -SO-, -SO2- or -O-; W is CH=CH or CH2-CH2; o is 1 to 5; n is 1 to 10; m is 0 to 7; T and Z, same or different, represent oxygen or a direct bond; R<2> and R<3>, same or different, represent hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano or nitro groups; A represents carboxyl, tetrazolyl, CO2R<4>, CONR<5>R<6> or nitrile group wherein R<4> is lower alkyl and R<5> and R<6> are H, lower alkyl, alkylsulfonyl, arlysulfonyl or R5 and R6 together are an alkylene chain forming a ring; and R is <CHEM> wherein B represents carboxyl, tetrazolyl, CO2R<4>, CONR<5>R<6> or nitrile group wherein R<4> is lower alkyl and R<5> and R<6> are H, lower alkyl, alkylsulfonyl, arlysulfonyl or R5 and R6 together are an alkylene chain forming a ring; R<7> and R<8>, same or different, represent H or lower alkyl; R<9> represents -OH, -O-alkyl, NH2 or a NHCH2CO2H group; and R<1><0> is H, alkyl, alkoxy, halogen, CF3, CF3O, CN or NO2.
IPC 1-7
IPC 8 full level
A61K 31/19 (2006.01); A61K 31/41 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); C07C 43/23 (2006.01); C07C 233/24 (2006.01); C07C 323/56 (2006.01); C07C 323/60 (2006.01); C07C 323/62 (2006.01); C07D 257/04 (2006.01); C07D 303/38 (2006.01); C07F 9/50 (2006.01); C07F 9/54 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 11/00 (2017.12); C07C 323/56 (2013.01); C07C 323/60 (2013.01); C07C 323/62 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
EP 0410241 A1 19910130; EP 0410241 B1 19931020; AT E96149 T1 19931115; CA 2021995 A1 19910128; DD 299177 A5 19920402; DE 69004023 D1 19931125; DE 69004023 T2 19940217; DK 0410241 T3 19931213; ES 2059915 T3 19941116; JP H03118360 A 19910520
DOCDB simple family (application)
EP 90113512 A 19900714; AT 90113512 T 19900714; CA 2021995 A 19900726; DD 34307090 A 19900725; DE 69004023 T 19900714; DK 90113512 T 19900714; ES 90113512 T 19900714; JP 19638690 A 19900726