Title (en)

IFN-beta 2/IL-6 receptor, its preparation and pharmaceutical compositions containing it.

Title (de)

IFN-beta 2/IL-6-Rezeptor, seine Herstellung und diesen Rezeptor enthaltende pharmazeutische Mischung.

Title (fr)

Récepteur d'iFN-bêta 2/IL-6, sa préparation et composition pharmaceutique le contenant.

Publication

EP 0413908 A2 19910227 (EN)

Application

EP 90110487 A 19900601

Priority

• IL 9048889 A 19890601
• IL 9244489 A 19891126

Abstract (en)

Human natural IFN- beta 2/IL-6 receptor and its soluble extracellular fragment are provided in substantially purified form and are shown to stimulate and to enhance beneficial effects of IFN- beta 2/IL-6, such as its antiproliferative activity. Polyclonal and monoclonal antibodies raised against the soluble fragment of the receptor are also provided.

IPC 1-7

A61K 37/02; A61K 37/66; C07K 13/00; C12N 15/12; C12P 21/02; C12P 21/08

IPC 8 full level

G01N 33/53 (2006.01); A61K 38/00 (2006.01); A61K 38/21 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 1/18 (2006.01); C07K 1/20 (2006.01); C07K 1/22 (2006.01); C07K 14/00 (2006.01); C07K 14/52 (2006.01); C07K 14/54 (2006.01); C07K 14/555 (2006.01); C07K 14/565 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 16/00 (2006.01); C12N 15/12 (2006.01); C12P 21/00 (2006.01); C12P 21/08 (2006.01); G01N 33/577 (2006.01); C12R 1/91 (2006.01)

CPC (source: EP US)

A61K 38/215 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); C07K 14/715 (2013.01 - EP US); C07K 14/7155 (2013.01 - EP US); Y10S 530/834 (2013.01 - EP US)

Citation (applicant)

• YAMASAKI, SCIENCE, vol. 241, pages 825 - 828
• HUYNH, T.V.: "DNA CLONING TECHNIQUES: A PRACTICAL APPROACH", 1984, IRL PRESS, pages: 49 - 78
• OIKE, Y., J. BIOL. CHEM., vol. 257, 1982, pages 9751 - 9758
• WATSON, J.D.: "MOLECULAR BIOLOGY OF THE GENE", 1977, W.A. BENJAMIN, INC., pages: 356 - 357
• LATHE, R., J. MOLEC. BIOL., vol. 183, 1985, pages 1 - 12
• MANIATIS, T.: "MOLECULAR CLONING: A LABORATORY MANUAL", 1982, COLD SPRING HARBOR PRESS
• MANIATIS, T., MOLECULAR CLONING: A LABOTATORY MANUAL
• HAYMES, B.T.: "NUCLEIC ACID HYBRIDIZATION: A PRACTICAL APPROACH", 1985, IRL PRESS
• KOHLER, NATURE, vol. 256, 1975, pages 495
• KOHLER, EUR. J. IMMUNOL., vol. 6, 1976, pages 511
• R.A. HOCK; M.D. HOLLENEBERG, J. BIOL. CHEM., vol. 255, October 1980 (1980-10-01), pages 10731 - 10736
• R.A. HOCK; M.D. HOLLENEBERG, J. BIOL. CHEM., vol. 255, 1980, pages 10731 - 10736
• LAEMMLI U.K., NATURE, vol. 227, 1970, pages 680
• OAKLEY, B.R., ANAL. BIOCHEM., vol. 105, pages 361
• TOWBIN, H., PROC. NATL. ACAD. SCI. USA, vol. 76, 1979, pages 4350 - 4354
• WILLCHEK; MIRON, METHODS IN ENZYMOLOGY, vol. 34, 1979, pages 72 - 76
• NORDAN, R.P.; POTTER, M., SCIENCE, vol. 233, 1986, pages 566 - 568

Designated contracting state (EPC)

CH DE FR GB IT LI

DOCDB simple family (publication)

EP 0413908 A2 19910227; EP 0413908 A3 19910807; EP 0413908 B1 19960925; EP 0413908 B2 20050803; DE 69028671 D1 19961031; DE 69028671 T2 19970220; DE 69028671 T3 20060112; JP 3542127 B2 20040714; JP H03157400 A 19910705; US 5216128 A 19930601; US 5621077 A 19970415

DOCDB simple family (application)

EP 90110487 A 19900601; DE 69028671 T 19900601; JP 14423590 A 19900601; US 32978594 A 19941027; US 53058090 A 19900530