EP 0414807 A4 19910703 - HUMAN MAMMARY CELL GROWTH INHIBITOR AND METHODS OF PRODUCTION AND USE
Title (en)
HUMAN MAMMARY CELL GROWTH INHIBITOR AND METHODS OF PRODUCTION AND USE
Publication
Application
Priority
US 19665788 A 19880520
Abstract (en)
[origin: WO8911492A1] A human mammary cell growth inhibitor, and novel compositions comprising enhanced and purified concentrations thereof, inhibits the growth of human mammary cells. Inhibitor of the present invention purified by monoclonal antibody affinity chromatography comprises a thermolabile protein and has peaks of inhibitory activity at molecular weights of about 47,000 and about 63,000-67,000, as determined by SDS-PAGE. The inhibitory activity of the inhibitor is mammary cell specific, and is both calcium and dose-dependent. Increased production of the inhibitor can be induced by growth of inhibitor-secreting human mammary cells in low concentrations of calcium. The inhibitor can be used prophylactically to decrease the risk of breast cancer, to screen for the risk or presence of breast cancer, and as a therapeutic agent for the treatment of breast cancer.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61P 35/00 (2006.01); C07K 1/22 (2006.01); C07K 14/00 (2006.01); C07K 14/435 (2006.01); C07K 14/475 (2006.01); C07K 16/22 (2006.01); C12N 15/02 (2006.01); C12P 21/00 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01); C12R 1/91 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); C07K 14/475 (2013.01); C07K 16/22 (2013.01); G01N 33/57415 (2013.01); A61K 38/00 (2013.01); C07K 2317/74 (2013.01)
Citation (search report)
- No further relevant documents have been disclosed.
- See references of WO 8911492A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8911492 A1 19891130; EP 0414807 A1 19910306; EP 0414807 A4 19910703; JP H05506423 A 19930922
DOCDB simple family (application)
US 8902214 W 19890522; EP 89906658 A 19890522; JP 50637389 A 19890522