EP 0416094 B1 19961023 - PARATHYROID HYPERTENSIVE FACTOR
Title (en)
PARATHYROID HYPERTENSIVE FACTOR
Title (de)
HYPERTENSIVER FAKTOR DES PARATHYROIDS
Title (fr)
FACTEUR HYPERTENSIF DE LA PARATHYROIDE
Publication
Application
Priority
- US 9001577 W 19900322
- US 32745089 A 19890322
- US 46048290 A 19900103
Abstract (en)
[origin: WO9011074A1] A new circulating factor from the parathyroid gland of some hypertensive mammals has been isolated and characterized. Polyclonal and monoclonal antibodies raised against this factor are usable as a screen for the presence of the factor. The factor is involved in the control of calcium uptake in cells. Hypertensive mammals may be treated to lower mean blood pressure by administering a calcium channel blocking agent together with one or both of a calcium supplement and Vitamin D. The hypotensive effect of this combination is synergistic and the dose response is more predictable than the administration of any of these agents singly.
IPC 1-7
A61K 31/275; A61K 31/44; A61K 31/55; A61K 31/59; A61K 35/55; A61K 39/395
IPC 8 full level
G01N 33/53 (2006.01); A61K 31/275 (2006.01); A61K 31/44 (2006.01); A61K 31/455 (2006.01); A61K 31/55 (2006.01); A61K 31/59 (2006.01); A61K 33/10 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 49/00 (2006.01); A61P 9/12 (2006.01); C07K 1/20 (2006.01); C07K 1/34 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 14/635 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); G01N 33/50 (2006.01); G01N 33/577 (2006.01)
CPC (source: EP KR US)
A61K 31/275 (2013.01 - EP KR US); A61K 31/44 (2013.01 - EP US); A61K 31/55 (2013.01 - EP US); A61K 33/10 (2013.01 - EP US); A61P 9/12 (2017.12 - EP); C07K 14/4702 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9011074 A1 19901004; AT E144419 T1 19961115; AU 5412190 A 19901022; AU 643685 B2 19931125; AU 648802 B2 19940505; AU 7937691 A 19910912; CA 2030516 A1 19900923; CA 2030516 C 20001010; DE 69028971 D1 19961128; DE 69028971 T2 19970522; EP 0416094 A1 19910313; EP 0416094 A4 19920325; EP 0416094 B1 19961023; EP 0722735 A1 19960724; HU 9201180 D0 19920728; HU T70033 A 19950928; JP 2919607 B2 19990712; JP H03505333 A 19911121; KR 0169115 B1 19990115; KR 920700029 A 19920219; US 5354765 A 19941011
DOCDB simple family (application)
US 9001577 W 19900322; AT 90905941 T 19900322; AU 5412190 A 19900322; AU 7937691 A 19910627; CA 2030516 A 19900322; DE 69028971 T 19900322; EP 90905941 A 19900322; EP 95118628 A 19900322; HU 118092 A 19900322; JP 50586090 A 19900322; KR 900702493 A 19901122; US 91877592 A 19920727