EP 0427162 B1 19960508 - Novel insulin derivatives, their preparation and use, and a pharmaceutical composition thereof
Title (en)
Novel insulin derivatives, their preparation and use, and a pharmaceutical composition thereof
Title (de)
Neue Insulinderivate, Verfahren zu deren Herstellung, ihre Verwendung und eine sie enthaltende pharmazeutische Zubereitung
Title (fr)
Nouveaux dérivés de l'insuline, leur préparation, leur usage et une composition pharmaceutique les contenant
Publication
Application
Priority
DE 3936876 A 19891106
Abstract (en)
[origin: EP0427162A1] Insulin derivatives of the formula III <IMAGE> in which a) R<30> + R<31> together = OH or b) R<30> = residue of a neutral, genetically encodable L-amino acid and R<31> = OH or a physiologically acceptable organic group which is basic in nature and has up to 50 C atoms, in whose structure 0 to 3 alpha -amino acids are involved and whose optionally present terminal carboxyl group can be free, in the form of an ester, of an amide or of a lactone, or reduced to CH2OH, and c) R<A-1> = residue of a genetically encodable L-amino acid or a physiologically acceptable organic group with up to 50 C atoms, with the exception of the cases in which simultaneously R<30> = Ala, R<31> = OH, R<A-1> = Lys or Arg, and the A chain and B chain are the sequences of bovine insulin, and the physiologically tolerated salts thereof. <??>The compounds are suitable for the treatment of diabetes mellitus, have a delayed action profile and are very well tolerated.
IPC 1-7
IPC 8 full level
C12P 21/06 (2006.01); A61K 38/28 (2006.01); A61P 3/08 (2006.01); A61P 3/10 (2006.01); C07K 1/06 (2006.01); C07K 14/575 (2006.01); C07K 14/62 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP KR US)
A61P 3/08 (2017.12 - EP); A61P 3/10 (2017.12 - EP); C07K 14/62 (2013.01 - EP US); C12N 15/11 (2013.01 - KR)
Citation (examination)
"Binding of insulin to bovine liver plasma membrane"
Designated contracting state (EPC)
AT BE CH DE DK ES FR GB GR IT LI LU NL SE
DOCDB simple family (publication)
EP 0427162 A1 19910515; EP 0427162 B1 19960508; AT E137765 T1 19960515; AU 6577290 A 19910509; CA 2029289 A1 19910507; DE 3936876 A1 19910523; DE 59010316 D1 19960613; DK 0427162 T3 19960916; ES 2087879 T3 19960801; FI 905439 A0 19901102; GR 3020095 T3 19960831; HU 205773 B 19920629; HU 907026 D0 19910528; HU T55804 A 19910628; IE 903978 A1 19910508; IL 96239 A0 19910816; JP 3131215 B2 20010131; JP H03169895 A 19910723; KR 910009930 A 19910628; NO 904808 D0 19901105; NO 904808 L 19910507; PT 95788 A 19910913; US 5149716 A 19920922; ZA 908842 B 19910828
DOCDB simple family (application)
EP 90121101 A 19901103; AT 90121101 T 19901103; AU 6577290 A 19901105; CA 2029289 A 19901105; DE 3936876 A 19891106; DE 59010316 T 19901103; DK 90121101 T 19901103; ES 90121101 T 19901103; FI 905439 A 19901102; GR 960401457 T 19960530; HU 702690 A 19901105; IE 397890 A 19901105; IL 9623990 A 19901105; JP 29737690 A 19901105; KR 900017864 A 19901106; NO 904808 A 19901105; PT 9578890 A 19901105; US 60383590 A 19901026; ZA 908842 A 19901105