EP 0427781 A1 19910522 - OZONIDES OF TERPENES AND THEIR MEDICAL USES.
Title (en)
OZONIDES OF TERPENES AND THEIR MEDICAL USES.
Title (de)
OZONIDE VON TERPENEN UND DEREN MEDIZINISCHE VERWENDUNGEN.
Title (fr)
OZONIDES DE TERPENES ET LEURS APPLICATIONS MEDICALES.
Publication
Application
Priority
US 21137888 A 19880624
Abstract (en)
[origin: WO8912626A1] Ozonides of terpenes are disclosed. Terpenes which are believed to be pharmacologically active when prepared in accordance with the present invention include: limonene, citronella, alpha-carotene, beta-carotene, Vitamin A, linalool, linalyl acetate, or squalene. Other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include geraniol, limonene, alpha-pinene, loganin, cymene, farnesanes, eudesmanes, acoranes, cedranes, chamigranes, caryophyllanes, illudanes, humulenes, himachalenes, longifolanes, perhydroazulenes, quaianes, quaianolides, or germacranes. Still other compounds which are believed to make pharmacologically active terpene ozonides in accordance with the present invention include labdanes, clerodanes, abietic acid, phyllocladene, giberellins, ophiobolin A, retigeranic acid, gasgardic acid, lanosterol, euphol, oleanane, ursane, lupeol, hydroxyhopanone, lupanes, or hopanes. Other particular terpene compounds which are believed to make pharmacologically active terpene ozonides when prepared in accordance with the present invention include B-selinene, zingibene, camphene, sabinene, ocimene, myrcene, nerol, citral A, citral B, farnesol, bisabolene, phytol, and cecropia hormone. A method of producing the terpene ozonides is also disclosed. Further, pharmaceutical preparations using these compositions are disclosed. Methods of medical treatment using these pharmaceutical preparations are also disclosed.
Abstract (fr)
L'invention concerne des ozonides de terpènes dont on a découvert qu'ils sont pharmacologiquement actifs lorsqu'on les prépare selon la présente invention, ils comprennent: limonène, citronelle, alpha-carotène, bêta-carotène, vitamine A, linalol, linalyle acétate, ou squalène. D'autres composés dont on a découvert qu'ils constituent des ozonides de terpènes pharmacologiquement actifs selon la présente invention comprennent: géraniol, limonène, alpha-pinène, loganine, cymène, farnésanes, eudesmanes, acoranes, cédranes, chamigranes, caryophyllanes, illudanes, humulènes, himachalènes, longifolanes, perhydroazulènes, quaianes, quaianolides, ou germacranes. D'autres composés dont on a découvert qu'ils constituent aussi des ozonides de terpènes pharmacologiquement actifs selon la présente invention comprennent: labdanes, clérodanes, acide abiétique, phyllocladène, gibérellines, ophioboline A, acide rétigéranique, acide gasgardique, lanostérol, euphol, oléanane, ursane, lupéol, hydroxyhopanone, lupanes, ou hopanes. D'autres composés de terpènes particuliers dont on a découvert qu'ils constituent des ozonides de terpènes pharmacologiquement actifs, lorsqu'on les prépare selon la présente invention, comprennent: B-sélinène, zingibène, camphène, sabinène, ocimène, myrcène, nérol, citral A, citral B, farnésol, bisabolène, phytol, et hormone de cécropia. L'invention concerne aussi un procédé de production d'ozonides de terpènes. Elle concerne en outre des préparations pharmaceutiques utilisant ces compositions, ainsi que des procédés de traitement médical utilisant lesdites préparations pharmaceutiques.
IPC 1-7
A61K 31/085; A61K 31/335; C07C 13/28; C07C 45/27; C07C 403/00; C07D 323/02
IPC 8 full level
A61K 31/08 (2006.01); A61K 8/00 (2006.01); A61K 31/335 (2006.01); A61K 31/357 (2006.01); A61P 17/00 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61Q 17/04 (2006.01); C07D 323/00 (2006.01); C07D 323/02 (2006.01); C07G 99/00 (2009.01)
CPC (source: EP)
A61P 17/00 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); C07D 323/02 (2013.01)
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 8912626 A1 19891228; AU 4058689 A 19900112; CA 1338083 C 19960227; EP 0427781 A1 19910522; EP 0427781 A4 19910821; JP H04502145 A 19920416
DOCDB simple family (application)
US 8902640 W 19890616; AU 4058689 A 19890616; CA 603585 A 19890622; EP 89909317 A 19890616; JP 50876989 A 19890616