Global Patent Index - EP 0432220 A4

EP 0432220 A4 19911204 - VACCINES AND DIAGNOSTIC ASSAYS FOR HAEMOPHILUS INFLUENZAE

Title (en)

VACCINES AND DIAGNOSTIC ASSAYS FOR HAEMOPHILUS INFLUENZAE

Publication

EP 0432220 A4 19911204 (EN)

Application

EP 89910798 A 19890831

Priority

  • US 8903779 W 19890831
  • US 23957288 A 19880901
  • US 39657289 A 19890821

Abstract (en)

[origin: WO9002557A1] Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methos of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host cells. The peptides, proteins, fusion proteins and viruses both ''live'' and ''inactivated'' are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides, proteins and fusion proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides, proteins and fusion proteins in hybridization assays is also described.

IPC 1-7

A61K 35/66; A61K 39/00; G01N 33/53; G01N 33/569

IPC 8 full level

A61K 39/102 (2006.01); A61K 39/145 (2006.01); A61K 39/395 (2006.01); A61K 39/40 (2006.01); C07K 1/00 (2006.01); C07K 7/08 (2006.01); C07K 14/00 (2006.01); C07K 14/005 (2006.01); C07K 14/195 (2006.01); C07K 14/285 (2006.01); C07K 14/705 (2006.01); C07K 16/00 (2006.01); C07K 16/12 (2006.01); C07K 19/00 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/569 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); C12R 1/19 (2006.01); C12R 1/21 (2006.01)

CPC (source: EP KR US)

A61K 39/145 (2013.01 - KR); C07K 14/285 (2013.01 - EP); C07K 16/1242 (2013.01 - EP); C12Q 1/689 (2013.01 - EP); G01N 33/56983 (2013.01 - EP); A61K 38/00 (2013.01 - EP); A61K 39/00 (2013.01 - EP KR US); C07K 2317/34 (2013.01 - EP); C07K 2319/035 (2013.01 - EP); C07K 2319/40 (2013.01 - EP)

Citation (search report)

  • [Y] WO 8804932 A1 19880714 - PRAXIS BIOLOG INC [US]
  • [E] WO 9010458 A1 19900920 - PRAXIS BIOLOG INC [US]
  • [Y] JOURNAL OF BACTERIOLOGY, vol. 169, no. 11, November 1987, pages 5201-5208, American Society for Microbiology; L.-M. GUZMAN-VERDUZCO et al.: "Fusion of Escherichia coli heat-stable enterotoxin and heat-labile enterotoxin B subunit"
  • [A] INFECTION AND IMMUNITY, vol. 52, no. 2, May 1986, pages 529-533, American Society, for Microbiology; D. DANIELSSON et al.: "Recombination near the antibiotic resistance locus penB results in antigenic veriation of gonococcal outer membrane protein I"
  • [A] GENE, vol. 64, 1988, pages 265-275, Elsevier Science Publishers B.V.; J. SANCHEZ et al.: "Hybrid enterotoxin LTA::STa proteins and their protection from degradation by in vivo association with B-subunits of Escherichia coli heat-labile enterotoxin"
  • See also references of WO 9002557A1

Designated contracting state (EPC)

AT BE CH DE FR GB IT LI LU NL SE

DOCDB simple family (publication)

WO 9002557 A1 19900322; AT E124420 T1 19950715; AU 3379693 A 19930429; AU 4228889 A 19900402; AU 631378 B2 19921126; AU 651030 B2 19940707; CA 1340888 C 20000201; DE 68923286 D1 19950803; DE 68923286 T2 19960307; DK 174965 B1 20040405; DK 35891 A 19910430; DK 35891 D0 19910228; EP 0432220 A1 19910619; EP 0432220 A4 19911204; EP 0432220 B1 19950628; JP 3073212 B2 20000807; JP H04502147 A 19920416; KR 0162488 B1 19981116; KR 0170752 B1 19991001; KR 900701291 A 19901201

DOCDB simple family (application)

US 8903779 W 19890831; AT 89910798 T 19890831; AU 3379693 A 19930226; AU 4228889 A 19890831; CA 609752 A 19890829; DE 68923286 T 19890831; DK 35891 A 19910228; EP 89910798 A 19890831; JP 51009389 A 19890831; KR 19980702574 A 19980408; KR 900700930 A 19900501