EP 0433312 A4 19911204 - CARRIER SYSTEM AND METHOD FOR ENHANCEMENT OF MAGNETIC RESONANCE IMAGING
Title (en)
CARRIER SYSTEM AND METHOD FOR ENHANCEMENT OF MAGNETIC RESONANCE IMAGING
Publication
Application
Priority
US 23546488 A 19880824
Abstract (en)
[origin: WO9001900A1] Enhanced magnetic resonance imaging contrast is provided by targeting paramagnetic material specifically to selected mammalian cell types. A carrier system for the paramagnetic material utilizes receptor mediated endocytosis to endow cell specificity and is formed by complexing the paramagnetic material to a glycoprotein-chelator conjugate. The conjugate is formed by bonding receptor-specific ligands to chelating agents through covalent bonding. The carrier not only exhibits a high degree of cell spcificity but also provides significant accumulation of the paramagnetic material within the cell to contribute to the improved enhancement of the magnetic resonance contrast.
IPC 1-7
IPC 8 full level
A61B 5/055 (2006.01); A61K 49/00 (2006.01); A61K 49/08 (2006.01); C07K 14/00 (2006.01); C09K 3/00 (2006.01); G01R 33/28 (2006.01)
CPC (source: EP)
A61K 49/085 (2013.01); A61K 49/14 (2013.01); A61K 51/0491 (2013.01); A61K 51/088 (2013.01); G01R 33/5601 (2013.01)
Citation (search report)
- [Y] EP 0273452 A2 19880706 - NIHON MEDIPHYSICS CO LTD [JP]
- [Y] EP 0268707 A2 19880601 - GEN HOSPITAL CORP [US], et al
- [XP] HEPATOLOGY, vol. 8, no. 5, September-October 1988, page 1253, abstract no. 140, Baltimore, US; G. WU et al.: "A hepatocyte-directed contrast agent for magnetic resonance imaging of hepatic tumors"
- See references of WO 9001900A1
Designated contracting state (EPC)
AT BE CH DE FR GB IT LI LU NL SE
DOCDB simple family (publication)
WO 9001900 A1 19900308; EP 0433312 A1 19910626; EP 0433312 A4 19911204; JP H04501560 A 19920319
DOCDB simple family (application)
US 8903545 W 19890817; EP 89909661 A 19890817; JP 50905689 A 19890817